刚果菌素和偏端霉素A，抗痘病毒抗生素。
Congocidine and distamycin A, antipoxvirus antibiotics.
作者信息
Becker Y, Asher Y, Zakay-Rones Z
出版信息
Antimicrob Agents Chemother. 1972 Jun;1(6):483-8. doi: 10.1128/AAC.1.6.483.
Abstract
The antibiotics congocidine and distamycin A inhibited the replication of Shope fibroma and vaccinia viruses in BSC(1) cells. Treatment of infected cultures with congocidine for a 12-hr period resulted in an irreversible inhibitory effect on virus development. A longer period of treatment with the antibiotic also resulted in inhibition of the residual infectious virions present in the treated cells. Distamycin A inhibited the replication of poxviruses, but its inhibitory effect was reversed when the antibiotic was removed from the infected cells even as long as 24 hr after treatment. The inhibitory effect of distamycin A and its reversibility resembled the antipoxvirus activity of rifampin.
摘要
抗生素刚果菌素和偏端霉素A可抑制肖普纤维瘤病毒和痘苗病毒在BSC(1)细胞中的复制。用刚果菌素处理感染的培养物12小时，会对病毒发育产生不可逆的抑制作用。用该抗生素进行更长时间的处理，也会抑制处理过的细胞中残留的感染性病毒粒子。偏端霉素A可抑制痘病毒的复制，但即使在处理后长达24小时，当从感染细胞中去除该抗生素时，其抑制作用也会逆转。偏端霉素A的抑制作用及其可逆性类似于利福平的抗痘病毒活性。
相似文献
1
Congocidine and distamycin A, antipoxvirus antibiotics.刚果菌素和偏端霉素A，抗痘病毒抗生素。
Antimicrob Agents Chemother. 1972 Jun;1(6):483-8. doi: 10.1128/AAC.1.6.483.
2
Mechanism of action of distamycin A and other antibiotics with antiviral activity.
Rev Physiol Biochem Pharmacol. 1976;75:69-96. doi: 10.1007/BFb0030485.
3
The effect of the antibiotics distamycin A and congocidine on the replication of herpes simplex virus.抗生素偏端霉素A和刚果杀菌素对单纯疱疹病毒复制的影响。
Isr J Med Sci. 1972 Aug-Sep;8(8):1225-30.
4
Structure-activity relationships of pyrrole amidine antiviral antibiotics III: preparation of distamycin and congocidine derivatives based on 2,5-disubstituted pyrroles.
J Pharm Sci. 1980 Nov;69(11):1334-8. doi: 10.1002/jps.2600691125.
5
[RNA fragments, in vivo inhibitors of Shope fibroma and vaccinia virus multiplication].
C R Acad Hebd Seances Acad Sci D. 1975 Feb 10;280(6):783-9.
6
The effect of distamycin A on some biochemical functions of tissue cultures infected with Herpes simplex virus.放线菌素A对感染单纯疱疹病毒的组织培养物某些生化功能的影响。
Farmaco Sci. 1976 Oct;31(10):705-13.
7
Synergic action of distamycin A and hydroxyurea on the reproduction of DNA viruses in cell cultures.放线菌素A与羟基脲对细胞培养中DNA病毒复制的协同作用。
Acta Virol. 1975 Jan;19(1):73-7.
8
Failure of inhibition of polyoma virus replication by distamycin A.放线菌素A对多瘤病毒复制的抑制失败。
Z Naturforsch C Biosci. 1976 Mar-Apr;31(3-4):214.
9
Inhibitory effect of Distamycin-A and a pyrazino-pyrazine derivative on tomato spotted wilt virus.
Antiviral Res. 1983 Aug;3(2):109-13. doi: 10.1016/0166-3542(83)90032-3.
10
[Experimental studies on the antiviral effect of distamycin A].
Antibiotiki. 1973 Mar;18(3):252-6.
引用本文的文献
1
Natural products influence bacteriophage infectivity.天然产物影响噬菌体的感染性。
Nat Prod Rep. 2025 Aug 18. doi: 10.1039/d5np00014a.
2
Comparative in silico study of congocidine congeners as potential inhibitors of African swine fever virus.比较刚果菌素同系物作为非洲猪瘟病毒潜在抑制剂的计算机研究。
PLoS One. 2019 Aug 28;14(8):e0221175. doi: 10.1371/journal.pone.0221175. eCollection 2019.
3
Therapeutic and prophylactic drugs to treat orthopoxvirus infections.用于治疗正痘病毒感染的治疗性和预防性药物。
Future Virol. 2008 Nov;3(6):595-612. doi: 10.2217/17460794.3.6.595.
4
Aurintricarboxylic acid inhibits the early stage of vaccinia virus replication by targeting both cellular and viral factors.金精三羧酸通过靶向细胞和病毒因子来抑制痘苗病毒复制的早期阶段。
J Virol. 2007 Mar;81(6):3027-32. doi: 10.1128/JVI.02531-06. Epub 2006 Dec 27.
5
Inhibition of yeast ribonucleic acid polymerases by thiolutin.硫藤黄素对酵母核糖核酸聚合酶的抑制作用。
J Bacteriol. 1973 Oct;116(1):245-56. doi: 10.1128/jb.116.1.245-256.1973.
本文引用的文献
1
THERAPEUTIC ACTION OF DISTAMYCIN A ON VACCINIA VIRUS INFECTIONS IN VIVO.
Chemotherapia (Basel). 1964;13:80-7. doi: 10.1159/000220347.
2
STUDIES ON THE ANTIVIRAL ACTIVITY OF DISTAMYCIN A.放线菌素A的抗病毒活性研究
Chemotherapia (Basel). 1964;13:65-79. doi: 10.1159/000220346.
3
STRUCTURE AND SYNTHESIS OF DISTAMYCIN A.放线菌素A的结构与合成
Nature. 1964 Sep 5;203:1064-5. doi: 10.1038/2031064a0.
4
The purification fo four strains of poxvirus.四种痘病毒株的纯化
Virology. 1962 Sep;18:9-18. doi: 10.1016/0042-6822(62)90172-1.
5
Observations on antiviral activity of netropsin.关于纺锤菌素抗病毒活性的观察。
Proc Soc Exp Biol Med. 1953 May;83(1):1-3. doi: 10.3181/00379727-83-20246.
6
Effect of distamycin a on the structure and template activity of DNA in RNA - polymerase system.偏端霉素A对RNA聚合酶系统中DNA的结构和模板活性的影响。
FEBS Lett. 1970 Mar 16;7(1):90-94. doi: 10.1016/0014-5793(70)80626-3.
7
Effect of Distamycin A on the template activity of DNA in a DNA polymerase system.偏端霉素A对DNA聚合酶系统中DNA模板活性的影响。
FEBS Lett. 1969 Aug;4(4):355-357. doi: 10.1016/0014-5793(69)80275-9.
8
Optical rotatory dispersion properties of nucleic acid complexes with the oligopeptide antibiotics distamycin A and netropsin.核酸与寡肽抗生素偏端霉素A和纺锤菌素复合物的旋光色散特性
FEBS Lett. 1970 Oct;10(5):339-342. doi: 10.1016/0014-5793(70)80467-7.
9
Studies on the complex of distamycin a with calf thymus DNA.关于放线菌素A与小牛胸腺DNA复合物的研究。
FEBS Lett. 1970 Oct 5;10(3):175-178. doi: 10.1016/0014-5793(70)80446-x.
10
Activity of a distamycin A on vaccinia virus infection of cell cultures.偏端霉素A对细胞培养物中牛痘病毒感染的活性。
Chemotherapia (Basel). 1964;9(3):144-57. doi: 10.1159/000220355.
Zotero 插件