促肾上腺皮质激素对大鼠肾上腺和肝脏蛋白质降解的影响。
The effect of adrenocorticotrophin on protein degradation in rat adrenal gland and liver.
作者信息
Canick J A, Villee D B
出版信息
Biochem J. 1974 Nov;144(2):397-402. doi: 10.1042/bj1440397.
Abstract
The rate of adrenal protein degradation appears to be slower in rats to which ACTH (adrenocorticotrophin) has been chronically administered. As measured by the exponential decay of radioactively labelled adrenal protein in vivo, the mean half-lives of total protein and of mitochondrial, microsomal and 18000g-supernatant protein were significantly longer in ACTH-treated animals. Experiments in which either [(3)H]leucine or NaH(14)CO(3) was used to label proteins showed that of the fractions studied, the effect on mitochondrial protein degradation was most pronounced. The half-lives of the same subcellular fractions in rat liver were not affected by ACTH. The possibility that the results might have been caused by changes in radioisotope reutilization and pool size is discussed.
摘要
在长期接受促肾上腺皮质激素（ACTH）治疗的大鼠中，肾上腺蛋白质降解速率似乎较慢。通过体内放射性标记肾上腺蛋白质的指数衰减来测量，促肾上腺皮质激素处理的动物中总蛋白质、线粒体、微粒体和18000g上清液蛋白质的平均半衰期明显更长。使用[³H]亮氨酸或NaH¹⁴CO₃标记蛋白质的实验表明，在所研究的组分中，对线粒体蛋白质降解的影响最为明显。大鼠肝脏中相同亚细胞组分的半衰期不受促肾上腺皮质激素的影响。文中讨论了这些结果可能是由放射性同位素再利用和库大小变化引起的可能性。
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Protein turnover in skeletal muscle. I. The measurement of rates of synthesis and catabolism of skeletal muscle protein using (14C)Na2CO3 to label protein.骨骼肌中的蛋白质周转。I. 使用(14C)Na2CO3标记蛋白质来测量骨骼肌蛋白质的合成和分解代谢速率。
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The mechanism of action of adrenocorticotropic hormone.促肾上腺皮质激素的作用机制。
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Influence of turnover rates on the responses of enzymes to cortisone.周转率对酶对可的松反应的影响。
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