发育中大鼠大脑中蛋白质降解率较低。
Lower rates of protein degradation in developing rat brain.
作者信息
Dahl J L, Weibel V J
出版信息
Biochem J. 1979 May 15;180(2):423-6. doi: 10.1042/bj1800423.
Abstract
Protein-degradation rates in developing rat brain were estimated from the decay in total radioactivity in proteins labelled by a single intraperitoneal injection of NaH14CO3 to 5-day-old animals. In contrast with previous reports, our results indicate that degradation rates are lower in developing than in adult brain and suggest that in brain, as has been observed in liver, adrenal gland, muscle, cultured mammalian cells and bacteria, reduced rates of protein degradation contribute to the increase in protein content under conditions of rapid growth.
摘要
通过向5日龄大鼠单次腹腔注射NaH¹⁴CO₃标记蛋白质，然后根据蛋白质中总放射性的衰减来估算发育中大鼠大脑的蛋白质降解率。与之前的报道相反，我们的结果表明，发育中大脑的蛋白质降解率低于成年大脑，这表明在大脑中，如同在肝脏、肾上腺、肌肉、培养的哺乳动物细胞和细菌中所观察到的那样，在快速生长条件下，蛋白质降解率降低有助于蛋白质含量的增加。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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