Branchevsky L L
Cor Vasa. 1972;20(2):152-8.
Phentolamine-induced blockade of alpha-adrenoreceptors and subsequent beta-adrenoreceptor stimulation by intravenous injection of adrenaline or phenylephrine (Mezaton) in anaesthtized dogs was accompanied by an elevation of plasma renin activitiy in peripheral blood and a reduction of renal excretion of sodium, potassium, and water. On the basis of his findings the author formulates his hypothesis that in extreme haemodynamic shifts, caused by changes in vascular tone, the renin-angiotensin system is the intrarenal mediator of natriuretic reaction, ensuring the coordination of circulatory and excretory functions in the overall regulation of water and electrolyte balance by modification of water and electrolyte excretion.
在麻醉犬中，酚妥拉明诱导的α-肾上腺素能受体阻滞以及随后静脉注射肾上腺素或去氧肾上腺素（美速克新命）对β-肾上腺素能受体的刺激，伴随着外周血中血浆肾素活性升高以及肾脏钠、钾和水排泄减少。基于这些发现，作者提出他的假说：在由血管张力变化引起的极端血流动力学改变中，肾素-血管紧张素系统是肾内利钠反应的介质，通过改变水和电解质排泄来确保循环和排泄功能在水和电解质平衡整体调节中的协调。
