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巨噬细胞的功能异质性

Functional heterogeneity of macrophages.

作者信息

Kávai M, Laczkó J, Csaba B

出版信息

Immunology. 1979 Apr;36(4):729-32.

PMID:437846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457648/
Abstract

The antibody-binding activities of rabbit peritoneal macrophages separated on discontinuous gradients of Ficoll were investigated. The antibody was rabbit anti-ovalbumin IgG labelled with 125I. Of the five fractions obtained, one macrophage fraction was found to bind substantially more antibody than the others. These macrophages possessed more Fc receptor sites than the others and the number of Fc receptors (n) and the association constant (K) of these cells was calculated. By electron microscopy, the phagocytic activity of the subpopulation with most Fc receptors was less than that of the others.

摘要

研究了在不连续的Ficoll梯度上分离的兔腹膜巨噬细胞的抗体结合活性。抗体是用125I标记的兔抗卵清蛋白IgG。在获得的五个组分中，发现一个巨噬细胞组分比其他组分结合的抗体要多得多。这些巨噬细胞比其他巨噬细胞拥有更多的Fc受体位点，并计算了这些细胞的Fc受体数量（n）和结合常数（K）。通过电子显微镜观察，Fc受体最多的亚群的吞噬活性低于其他亚群。

相似文献

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引用本文的文献

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本文引用的文献

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Studies on the mechanism of binding of immune complexes to phagocytes.免疫复合物与吞噬细胞结合机制的研究。
Nature. 1969 Jun 28;222(5200):1290-1. doi: 10.1038/2221290a0.
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Functional heterogeneity of macrophages: subclasses of peritoneal macrophages with different antigen-binding activities and immune complex receptors.巨噬细胞的功能异质性：具有不同抗原结合活性和免疫复合物受体的腹膜巨噬细胞亚类
Immunology. 1974 May;26(5):1025-37.
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The macrophage receptor for IgG: number and affinity of binding sites.免疫球蛋白G的巨噬细胞受体：结合位点的数量与亲和力
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Functional and morphological heterogeneity among rabbit peritoneal macrophages.兔腹膜巨噬细胞之间的功能和形态异质性。
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Purification and some properties of rabbit anti-ovalbumin.兔抗卵清蛋白的纯化及某些特性
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The importance of antibody concentration, binding constant, and heterogeneity in the suppression of immunity to the Rh factor.
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Isolation of antibodies by gel-filtration.通过凝胶过滤分离抗体。
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A method of trace iodination of proteins for immunologic studies.一种用于免疫学研究的蛋白质微量碘化方法。
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The fixation of heterocytophylic antibodies to macrophages.异嗜性抗体与巨噬细胞的结合。
Int Arch Allergy Appl Immunol. 1976;50(2):206-11. doi: 10.1159/000231497.

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