Plaeger-Marshall S, Wilson L A, Smith J W
Infect Immun. 1982 Jan;35(1):151-6. doi: 10.1128/iai.35.1.151-156.1982.
The permissiveness of rabbit monocytes and macrophages for herpes simplex virus was examined. Peripheral blood monocytes, alveolar macrophages, and peritoneal exudate macrophages were studied for their ability to replicate herpes simplex virus strains RE and KOS. Results indicated different degrees of interaction with virus depending on the macrophage type. Only peritoneal exudate macrophages showed evidence of virus replication. Productive infection was limited, with only a small number of cells (0.02%) yielding infectious virus. Higher numbers of cells appeared to be abortively infected. Approximately 40% expressed antigens, whereas virtually all were killed by exposure to virus. Coreless particles were seen by electron microscopy in about one-third. Alveolar macrophages were also killed by virus and showed evidence of virus adsorption, but showed no indication of productive or abortive infection. Monocytes neither adsorbed nor replicated virus, and viability was unaffected. Results suggest that differences in degrees of cellular maturation or differentiation, or both, account for the spectrum of interactions seen between herpes simplex virus and rabbit macrophages.
研究了兔单核细胞和巨噬细胞对单纯疱疹病毒的易感性。对外周血单核细胞、肺泡巨噬细胞和腹腔渗出液巨噬细胞复制单纯疱疹病毒RE株和KOS株的能力进行了研究。结果表明，根据巨噬细胞类型的不同，与病毒的相互作用程度也不同。只有腹腔渗出液巨噬细胞显示出病毒复制的证据。有效感染是有限的，只有少数细胞（0.02%）产生传染性病毒。更多的细胞似乎受到了流产感染。约40%的细胞表达抗原，而实际上所有细胞在接触病毒后均被杀死。电子显微镜观察发现约三分之一的细胞中有无核颗粒。肺泡巨噬细胞也被病毒杀死，并显示出病毒吸附的证据，但没有有效感染或流产感染的迹象。单核细胞既不吸附也不复制病毒，其活力不受影响。结果表明，细胞成熟度或分化程度的差异，或两者兼而有之，是单纯疱疹病毒与兔巨噬细胞之间观察到的相互作用谱的原因。
