Sulica A, Gherman M, Medeşan C, Sjöquist J, Gheţie V
Eur J Immunol. 1979 Dec;9(12):979-84. doi: 10.1002/eji.1830091212.
Evidence is presented concerning the existence on mouse peritoneal macrophages of two separate and distinct Fc receptors, one for cytophilic monomeric IgG (mIgG) and the other for polymeric IgG. The latter Fc receptor recognizes both heat-aggregated IgG and antigen-complexed IgG. The major findings of our studies are: (a) the different susceptibility of the two Fc receptor types by pronase, trypsin or phospholipase C; (b) the independent modulation of these two binding sites on the cell membrane; (c) the inability of mIgG to inhibit the binding of particulate antigen-complexed IgG ligand; (d) the ability of mIgG molecules which are devoid of the cytophilic property to attach to the macrophage surface upon their polymerization induced by heating or antigen. The results are discussed in terms of "cytophilic" and "opsonic" Fc receptor types which may provide different functional abilities for normal macrophages.
有证据表明，小鼠腹膜巨噬细胞上存在两种不同的Fc受体，一种是嗜细胞性单体IgG（mIgG）的受体，另一种是聚合IgG的受体。后一种Fc受体可识别热聚集IgG和抗原复合IgG。我们研究的主要发现如下：（a）两种Fc受体类型对链霉蛋白酶、胰蛋白酶或磷脂酶C的敏感性不同；（b）细胞膜上这两个结合位点的独立调节；（c）mIgG无法抑制颗粒性抗原复合IgG配体的结合；（d）缺乏嗜细胞特性的mIgG分子在受热或抗原诱导发生聚合后能够附着于巨噬细胞表面。根据“嗜细胞性”和“调理素性”Fc受体类型对结果进行了讨论，这两种受体类型可能为正常巨噬细胞提供不同的功能能力。
