Laxdal O E, Blake R M, Cartmill T, Robertson H E
Can Med Assoc J. 1966 Jan 22;94(4):159-63.
Seventy-one children were studied intensively in an attempt to identify both bacterial and viral agents responsible for acute otitis media. Studies included processing of nasopharyngeal secretions and of fluid obtained by needle aspiration of the middle ear. Ear fluid was consistently sterile for viruses but grew bacterial pathogens in 10 of 20 specimens. Nose and throat cultures yielded bacterial pathogens in less than 40% and were of little value in predicting middle-ear flora. Influenza C was isolated from one of 48 throat washings. Viral serology was compatible with influenza A2 and adenovirus infection in two cases. Bacterial and viral agents could not be incriminated in nearly 50% of the children studied.
对71名儿童进行了深入研究，试图确定导致急性中耳炎的细菌和病毒病原体。研究包括对鼻咽分泌物以及通过中耳穿刺抽取的液体进行处理。中耳积液一直未检测出病毒，但在20个样本中有10个培养出了细菌病原体。鼻腔和咽喉培养物中细菌病原体的检出率不到40%，对预测中耳菌群价值不大。在48次咽喉冲洗样本中有1份分离出了C型流感病毒。在两例病例中，病毒血清学检测结果与A2型流感病毒和腺病毒感染相符。在近50%的研究对象儿童中，无法确定细菌和病毒病原体。
