Bubeník J, Perlmann P, Fenyö E M, Jandlová T, Suhajová E, Malkovský M
Int J Cancer. 1979 Mar 15;23(3):392-6. doi: 10.1002/ijc.2910230318.
The correlation between tumorigenicity and cell-surface adhesiveness was investigated in eight mouse fibroblastoid cell lines. Four of the lines (Mc 11-Mc 15) were derived from mouse MC-induced fibrosarcomas, two were derivatives of L cells (A9, A9HT), and two (clone 3 and clone 7 H7F4) were obtained by fusion of A9HT cells with normal diploid mouse lymphocytes. Quantitative comparison of cellular adhesive properties by the Latex particle adherence assay indicated that higher malignancy of some lines (Mc 11, 13, 14, A9HT cl 7 H7F4) was regularly associated with lower cell-surface adhesiveness and conversely, lower malignancy of the other lines (Mc 15, A9, cl 3) with high cell-surface adhesiveness. The differences in adhesiveness of cell lines of high and low malignancy were determined by cell subsets not attaching and Latex particles (24.6-61.9% of cells in highly and 4.6-12.0% in slightly tumorigenic lines) and cell subsets attaching more than 25 Latex particles per cell (14.6-17.2% in highly and 46.1-71.4% in less tumorigenic lines).
在八种小鼠成纤维细胞样细胞系中研究了致瘤性与细胞表面黏附性之间的相关性。其中四种细胞系（Mc 11 - Mc 15）源自小鼠MC诱导的纤维肉瘤，两种是L细胞的衍生物（A9、A9HT），另外两种（克隆3和克隆7 H7F4）是通过A9HT细胞与正常二倍体小鼠淋巴细胞融合获得的。通过乳胶颗粒黏附试验对细胞黏附特性进行定量比较表明，一些细胞系（Mc 11、13、14、A9HT cl 7 H7F4）较高的恶性程度通常与较低的细胞表面黏附性相关，反之，其他细胞系（Mc 15、A9、克隆3）较低的恶性程度与较高的细胞表面黏附性相关。高恶性和低恶性细胞系黏附性的差异由不黏附的细胞亚群和乳胶颗粒决定（高致瘤性细胞系中24.6 - 61.9%的细胞，低致瘤性细胞系中4.6 - 12.0%的细胞）以及每个细胞黏附超过25个乳胶颗粒的细胞亚群（高致瘤性细胞系中14.6 - 17.2%的细胞，低致瘤性细胞系中46.1 - 71.4%的细胞）。
