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1
Assay of the possible organization of particle-bound enzymes with squalene synthetase and squalene oxidocyclase systems.对与角鲨烯合成酶和角鲨烯氧化环化酶系统结合的颗粒性酶可能的组织形式进行分析。
Biochem J. 1969 Feb;111(4):445-51. doi: 10.1042/bj1110445.
2
On the enzymes catalysing the transformation of squalene to lanosterol.关于催化角鲨烯转化为羊毛甾醇的酶。
Biochem J. 1969 Jul;113(3):19P-20P. doi: 10.1042/bj1130019pb.
3
Enzymatic studies on the oxidative cyclizations of squalene.关于角鲨烯氧化环化作用的酶学研究。
Biochem Soc Symp. 1970;29:35-43.
4
[Oxidative cyclization of squalene. Biosynthesis of sterols].[角鲨烯的氧化环化作用。固醇的生物合成]
Tanpakushitsu Kakusan Koso. 1970 Feb;15(2):82-92.
5
Enzymic conversion of farnesyl pyrophosphate to squalene.法尼基焦磷酸的酶促转化为角鲨烯。
Arch Biochem Biophys. 1966 Apr;114(1):200-15. doi: 10.1016/0003-9861(66)90322-5.
6
Studies in phytosterol biosynthesis. Mechanism of biosynthesis of cycloartenol.植物甾醇生物合成的研究。环阿屯醇的生物合成机制。
Biochem J. 1968 Apr;107(3):417-26. doi: 10.1042/bj1070417.
7
Artificial substrates in squalene and sterol biosynthesis.角鲨烯和甾醇生物合成中的人工底物。
J Biol Chem. 1972 Jun 10;247(11):3464-70.
8
Evidence from cell-free systems for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi.来自无细胞系统的证据表明，立枯丝核菌和樟疫霉的甾醇生物合成途径存在差异。
Biochem J. 1978 Feb 15;170(2):355-63. doi: 10.1042/bj1700355.
9
The nature of the hydrogen migrations in the cyclization of squalene oxide to lanosterol.
J Am Chem Soc. 1970 Apr 8;92(7):2059-64. doi: 10.1021/ja00710a044.
10
Inhibition of sterol biosynthesis by bacitracin.杆菌肽对甾醇生物合成的抑制作用。
Proc Natl Acad Sci U S A. 1972 May;69(5):1287-9. doi: 10.1073/pnas.69.5.1287.

引用本文的文献

1
Stereochemistry of enzyjme reactions at prochiral centers.前手性中心酶反应的立体化学
Naturwissenschaften. 1970 Sep;57(9):435-42. doi: 10.1007/BF00607727.

本文引用的文献

1
Sterospecificity of hydrogen transfer from reduced triphosphopyridine nucleotide to squalene during its synthesis from farnesyl pyrophosphate.在由法呢基焦磷酸合成角鲨烯的过程中，还原型三磷酸吡啶核苷酸向角鲨烯的氢转移的立体特异性。
Biochem Biophys Res Commun. 1962 Jan 24;6:438-42. doi: 10.1016/0006-291x(62)90371-6.
2
Studies on the biosynthesis of cholesterol. XVI. Chemical synthesis of 1-H2-3-2-C-14- and 1-D2-2-C-14-trans-trans-farnesyl pyrophosphate and their utilization in squalene biosynthesis.胆固醇生物合成的研究。十六。1-H₂-3-²C-¹⁴-和1-D₂-2-²C-¹⁴-反式-反式-法呢基焦磷酸的化学合成及其在角鲨烯生物合成中的应用。
J Biol Chem. 1962 Jan;237:56-61.
3
STEREOCHEMISTRY AT THE CENTER OF SQUALENE DURING ITS BIOSYNTHESIS FROM FARNESYL PYROPHOSPHATE AND SUBSEQUENT CONVERSION TO CHOLESTEROL.在焦磷酸法呢酯生物合成角鲨烯以及随后将其转化为胆固醇的过程中，角鲨烯中心的立体化学。
J Biol Chem. 1964 Jan;239:98-101.
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Studies of cholesterol biosynthesis. IV. Reduction of lanosterol to 24,25-dihydrolanosterol by rat liver homogenates.胆固醇生物合成的研究。IV. 大鼠肝脏匀浆将羊毛甾醇还原为24,25-二氢羊毛甾醇
J Biol Chem. 1963 Apr;238:1283-6.
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Studies on the biosynthesis of cholesterol. XV. Mechanism of squalene biosynthesis from farnesyl pyrophosphate and from mevalonate.胆固醇生物合成的研究。十五、由法呢基焦磷酸酯及甲羟戊酸合成角鲨烯的机制。
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On the conversion of squalene to lanosterol in vitro.关于角鲨烯在体外转化为羊毛甾醇的研究。
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7
The biosynthesis of cholesterol from acetate-1-C14 by cellular fractions of rat liver.用大鼠肝脏细胞组分从乙酸-1-C14合成胆固醇
J Biol Chem. 1956 Sep;222(1):1-15.
8
Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis.胆固醇生物合成的研究 XIX. 角鲨烯生物合成中氢消除和碳-碳键形成的立体化学过程。
Proc R Soc Lond B Biol Sci. 1966 Jan 18;163(993):492-514. doi: 10.1098/rspb.1966.0004.
9
Studies on the biosynthesis of cholesterol. 18. The stereospecificity of mevaldate reductase and the biosynthesis of asymmetrically labelled farnesyl pyrophosphate.胆固醇生物合成的研究。18. 甲羟戊酸还原酶的立体特异性及不对称标记法呢基焦磷酸的生物合成。
Proc R Soc Lond B Biol Sci. 1966 Jan 18;163(993):465-91. doi: 10.1098/rspb.1966.0003.

对与角鲨烯合成酶和角鲨烯氧化环化酶系统结合的颗粒性酶可能的组织形式进行分析。

Assay of the possible organization of particle-bound enzymes with squalene synthetase and squalene oxidocyclase systems.

作者信息

Etemadi A H, Popják G, Cornforth J W

出版信息

Biochem J. 1969 Feb;111(4):445-51. doi: 10.1042/bj1110445.

DOI:10.1042/bj1110445
PMID:4388240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1187563/
Abstract

Lanosterol was biosynthesized in pig liver homogenate from [4,8,12-(14)C(3)]farnesyl pyrophosphate and [4S-4-(3)H]NADPH through the intermediary formation of squalene labelled asymmetrically with (3)H. The biosynthetic lanosterol, freed from labelled 24,25-dihydrolanosterol, which was also synthesized, was converted into 24,25-dihydrolanosteryl acetate and subjected to chemical degradations to locate the position(s) of the (3)H label in the molecule. The ratio of (3)H at C-11 to that at C-12 was found to be 1.28. Although a certain inequality of labelling was thus indicated, experimental uncertainties did not permit the conclusion that the asymmetrically labelled squalene might have been cyclized preferentially from one end.

摘要

羊毛甾醇在猪肝匀浆中由[4,8,12-(14)C(3)]法呢基焦磷酸酯和[4S-4-(3)H]NADPH生物合成，通过(3)H不对称标记的角鲨烯的中间形成过程。从同样合成的标记的24,25-二氢羊毛甾醇中分离出的生物合成羊毛甾醇被转化为24,25-二氢羊毛甾醇乙酸酯，并进行化学降解以确定分子中(3)H标记的位置。发现C-11处的(3)H与C-12处的(3)H的比率为1.28。尽管由此表明了标记存在一定的不均衡性，但实验的不确定性不允许得出不对称标记的角鲨烯可能优先从一端环化的结论。