垂体切除和断奶后泌乳大鼠乳腺酶模式的变化。
Changes in the enzyme pattern of the mammary gland of the lactating rat after hypophysectomy and weaning.
作者信息
Jones E A
出版信息
Biochem J. 1967 May;103(2):420-7. doi: 10.1042/bj1030420.
Abstract
- The enzymes glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, phosphoglucomutase, UDP-glucose pyrophosphorylase, phosphofructokinase, ATP-citrate lyase and acetyl-CoA carboxylase have been assayed in rat mammary glands in various stages of involution after hypophysectomy and weaning. 2. After hypophysectomy all seven enzymes decline in activity over a 12-16hr. period but the extent of the decline varies, with acetyl-CoA carboxylase becoming almost totally inactive, ATP-citrate lyase and phosphofructokinase showing a large decrease, and the remaining enzymes a less marked decline. 3. Within 24hr. of removing the litter a change in the pattern of enzyme activity is found very similar to that after hypophysectomy. 4. The significance of these results is discussed in relation to the endocrine control of mammary gland metabolism and the mechanisms of involution.
摘要
- 已对垂体切除和断奶后处于不同退化阶段的大鼠乳腺中的葡萄糖6-磷酸脱氢酶、6-磷酸葡萄糖酸脱氢酶、磷酸葡萄糖变位酶、UDP-葡萄糖焦磷酸化酶、磷酸果糖激酶、ATP-柠檬酸裂解酶和乙酰辅酶A羧化酶进行了测定。2. 垂体切除后，所有七种酶的活性在12 - 16小时内均下降，但下降程度各不相同，乙酰辅酶A羧化酶几乎完全失活，ATP-柠檬酸裂解酶和磷酸果糖激酶大幅下降，其余酶的下降则不太明显。3. 在取出幼崽后的24小时内，发现酶活性模式的变化与垂体切除后的非常相似。4. 结合乳腺代谢的内分泌控制和退化机制对这些结果的意义进行了讨论。
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