Pitt C G, Jeffcoat A R, Zweidinger R A, Schindler A
J Biomed Mater Res. 1979 May;13(3):497-507. doi: 10.1002/jbm.820130313.
The maximum steady state flux, diffusion coefficients, and solubilities of five contraceptive steroids in homopolymers and copolymers of epsilon-caprolactone and DL-lactic acid were determined. The permeabilities of polymers of epsilon-caprolactone were comparable to silicone rubber and, by inference, are suitable for the construction of drug delivery devices. Poly(DL-lactic acid) was 10(4) times less permeable, although its permeability was significantly enhanced by additives.
测定了五种避孕甾体激素在ε-己内酯与DL-乳酸的均聚物和共聚物中的最大稳态通量、扩散系数和溶解度。ε-己内酯聚合物的渗透性与硅橡胶相当，因此可推断其适用于药物递送装置的构建。聚（DL-乳酸）的渗透性低10⁴倍，不过其渗透性会因添加剂而显著提高。
