Sangster J M, Kenwright M G, Walker M P, Pembroke A C
J Clin Pathol. 1979 Feb;32(2):154-7. doi: 10.1136/jcp.32.2.154.
A 63-year-old woman presented with Raynaud's phenomenon and extensive cold-induced livedo reticularis. A skin biopsy showed no abnormality of the blood vessels but the blood contained high titres of a very unusual autoantibody against the M blood group, most active at low temperatures. An IgM cryoglobulin was detected, and anti-M activity was found in this fraction. The cells of the patient were grouped as MM. The direct antiglobulin test was positive due to C3 component of complement bound to the red cells. The haematological and biochemical results indicate a mild haemolytic process, which is at present well compensated.
一名63岁女性出现雷诺现象及广泛的冷诱导网状青斑。皮肤活检显示血管无异常，但血液中含有高滴度的一种非常罕见的抗M血型自身抗体，在低温下活性最强。检测到IgM冷球蛋白，且该组分中存在抗M活性。患者的细胞血型为MM。由于补体C3成分结合于红细胞，直接抗球蛋白试验呈阳性。血液学和生化结果表明存在轻度溶血过程，目前代偿良好。
