Chapman J, Murphy M F, Waters A H
Vox Sang. 1982;42(5):272-7. doi: 10.1111/j.1423-0410.1982.tb00756.x.
A case of chronic cold haemagglutinin disease due to an IgM monoclonal (kappa) autoantibody with anti-M-like specificity is described in a patient with the MN phenotype. The autoantibody was present in very high titre and active at body temperature, but haemolysis was only mild. The direct antiglobulin test was positive due to C3d on the patient's red cells, and the autoantibody was able to bind complement to normal MM and MN cells with a marked dosage effect.
本文描述了一例MN血型表型患者因具有抗M样特异性的IgM单克隆（κ）自身抗体引起的慢性冷凝集素病。该自身抗体效价极高且在体温下具有活性，但溶血仅为轻度。由于患者红细胞上存在C3d，直接抗球蛋白试验呈阳性，并且该自身抗体能够以显著的剂量效应将补体结合到正常的MM和MN细胞上。
