重度抑郁症患者血浆11-羟基皮质类固醇水平对地塞米松抑制的抵抗性。
Resistance to suppression by dexamethasone of plasma 11-O.H.C.S. levels in severe depressive illness.
作者信息
Carroll B J, Martin F I, Davies B
出版信息
Br Med J. 1968 Aug 3;3(5613):285-7. doi: 10.1136/bmj.3.5613.285.
Abstract
Use of the midnight dexamethasone suppression test showed that the plasma 11-hydroxycorticosteroid (11-O.H.C.S.) level did not undergo its normal reduction in 14 out of 27 patients with severe depression. Resistance to dexamethasone suppression correlated with the clinical rating of the severity of depression, while recovery from depression was associated with return of normal responsiveness to dexamethasone. The explanation of these findings is unknown.
摘要
午夜地塞米松抑制试验结果显示，27例重度抑郁症患者中有14例血浆11 - 羟基皮质类固醇（11 - O.H.C.S.）水平未出现正常降低。对地塞米松抑制的抵抗与抑郁症严重程度的临床评分相关，而抑郁症的恢复与对地塞米松反应恢复正常有关。这些发现的原因尚不清楚。
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