[β受体阻滞剂普萘洛尔对豚鼠和支气管哮喘患者支气管收缩作用的研究]
[Studies of the bronchoconstrictor effect of the beta-receptor blocking agent propranolol in guinea pigs and patients with bronchial asthma].
作者信息
Herxheimer H, Langer I
出版信息
Klin Wochenschr. 1967 Nov 15;45(22):1149-53. doi: 10.1007/BF01727399.
Abstract
- The bronchoconstrictor effect of propranolol aerosol was investigated on guinea-pigs and on 5 patients with bronchial asthma. 2. In guinea-pigs a 12% propranolol aerosol regulare caused severe dyspnoea similar to that observed in the anaphylactic microshock. 3. The bronchial obstruction present in asthmatics became more pronounced after inhaling a 1% or 5% propranolol aerosol. 4. In guinea-pigs and in asthmatics the propranolol effect was significantly antagonized by atropine and by hexamethonium; guanethidine and mepyramine had no effect.
摘要
- 研究了普萘洛尔气雾剂对豚鼠和5例支气管哮喘患者的支气管收缩作用。2. 在豚鼠中，12%的普萘洛尔气雾剂常引发严重呼吸困难，类似于过敏性微休克时观察到的情况。3. 哮喘患者吸入1%或5%的普萘洛尔气雾剂后，支气管阻塞变得更加明显。4. 在豚鼠和哮喘患者中，阿托品和六甲铵可显著拮抗普萘洛尔的作用；胍乙啶和甲氧苄二胺则无作用。
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