大鼠脑和肝匀浆中的5-羟色胺代谢
5-Hydroxytryptamine metabolism in rat brain and liver homogenates.
作者信息
Feldstein A, Williamson O
出版信息
Br J Pharmacol. 1968 Sep;34(1):38-42. doi: 10.1111/j.1476-5381.1968.tb07948.x.
Abstract
- The metabolism of 5-hydroxyindoleacetaldehyde derived from 5-hydroxytryptamine incubated with tissue homogenates was studied as an indicator of aldehyde dehydrogenase and alcohol dehydrogenase activities.2. In liver and brain from rats, there were indications of the presence of one or more aldehyde dehydrogenases which were stimulated by NAD(+) to a greater extent than by NADP(+).3. In liver from rats, there were indications of the presence of one or more alcohol dehydrogenases, which were stimulated by NADH to a greater extent than by NADPH.4. In brain from rats, there were indications of the presence of one or more alcohol dehydrogenases which were stimulated by NADPH to a greater extent than by NADH.
摘要
研究了与组织匀浆一起孵育的5-羟色胺衍生的5-羟吲哚乙醛的代谢，以此作为醛脱氢酶和醇脱氢酶活性的指标。
在大鼠的肝脏和大脑中，有迹象表明存在一种或多种醛脱氢酶，其受NAD(+)刺激的程度大于受NADP(+)刺激的程度。
在大鼠的肝脏中，有迹象表明存在一种或多种醇脱氢酶，其受NADH刺激的程度大于受NADPH刺激的程度。
在大鼠的大脑中，有迹象表明存在一种或多种醇脱氢酶，其受NADPH刺激的程度大于受NADH刺激的程度。
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