Peters A R, Mepham T B
J Endocrinol. 1979 Mar;80(3):357-64. doi: 10.1677/joe.0.0800357.
Assay of corticosteroids in the plasma of guinea-pigs showed that concentrations were higher in lactating than in non-lactating and male animals. In five isolated perfused mammary gland experiments in which corticosteroids were at concentrations of 1,3--3,0 microgram/ml in the perfusate, equivalent to concentrations during lactation, the mean (+/- S.E.M.) uptake by the mammary gland was 900 +/- 210 ng g-1 h-1. In five experiments in which the concentrations of corticosteroid in the perfusate were 190--580 ng/ml, the uptake by the mammary gland was significantly lower (316 +/- 73 ng g-1 h-1; P less than 0.05). For the ten experiments there was a significant correlation between the concentration of corticosteroid in the perfusate and uptake by the mammary gland (P less than 0.05). No convincing evidence for a galactopoietic role of corticosteroids in the guinea-pig was obtained, although administration of cortisol signficantly stimulated the uptake of glutamine by the perfused gland.
对豚鼠血浆中皮质类固醇的检测表明，哺乳期动物血浆中皮质类固醇的浓度高于非哺乳期动物和雄性动物。在5个离体灌注乳腺实验中，灌注液中皮质类固醇的浓度为1.3 - 3.0微克/毫升，相当于哺乳期的浓度，乳腺的平均（±标准误）摄取量为900 ± 210纳克/克/小时。在另外5个实验中，灌注液中皮质类固醇的浓度为190 - 580纳克/毫升，乳腺的摄取量显著降低（316 ± 73纳克/克/小时；P < 0.05）。在这10个实验中，灌注液中皮质类固醇的浓度与乳腺摄取量之间存在显著相关性（P < 0.05）。尽管给予皮质醇能显著刺激灌注乳腺对谷氨酰胺的摄取，但未获得令人信服的证据表明皮质类固醇在豚鼠中具有催乳作用。
