Matthews W B, Read D J, Pountney E
J Neurol Neurosurg Psychiatry. 1979 Mar;42(3):250-5. doi: 10.1136/jnnp.42.3.250.
The effects of raising body temperature on the visual (VEP) and somatosensory (SEP) evoked potentials were observed in normal subjects and in patients with multiple sclerosis. The amplitude of the VEP was significantly reduced to the same degree after heating in normal subjects and in patients with multiple sclerosis but there was no effect on the latency of the potential. Changes in amplitude could not be related to reduction in acuity. In contrast, the cervical SEP was greatly disorganised after heating in many patients with multiple sclerosis while the only effect in normal subjects was to reduce the latency by increasing peripheral conduction velocity. These results suggest that heat caused conduction block in demyelinated axons in the sensory pathways of the cervical spinal cord.
在正常受试者和多发性硬化症患者中观察了体温升高对视觉诱发电位(VEP)和体感诱发电位(SEP)的影响。正常受试者和多发性硬化症患者在加热后VEP的波幅均显著降低至相同程度,但对电位的潜伏期没有影响。波幅的变化与视力下降无关。相比之下,许多多发性硬化症患者在加热后颈部SEP严重紊乱,而正常受试者中唯一的影响是通过增加外周传导速度来缩短潜伏期。这些结果表明,热导致颈脊髓感觉通路中脱髓鞘轴突的传导阻滞。