Regan D, Murray T J, Silver R
J Neurol Neurosurg Psychiatry. 1977 Nov;40(11):1083-91. doi: 10.1136/jnnp.40.11.1083.
Seven multiple sclerosis patients were cooled and four heated, but evoked potential delay changed in only five out 11 experiments. Control limits were set by cooling eight and heating four control subjects. One patient gave anomalous results in that although heating degraded perceptual delay and visual acuity, and depressed the sine wave grating MTF, double-flash resolution was improved. An explanation is proposed in terms of the pattern of axonal demyelination. The medium frequency flicker evoked potential test seems to be a less reliable means of monitoring the progress of demyelination in multiple sclerosis patients than is double-flash campimetry or perceptual delay campimetry, although in some situations the objectivity of the evoked potential test would be advantageous.
七名多发性硬化症患者接受了降温处理,四名接受了升温处理,但在11次实验中只有5次诱发电位延迟发生了变化。通过对八名对照受试者进行降温处理和四名对照受试者进行升温处理来设定控制界限。一名患者出现了异常结果,即尽管升温使知觉延迟和视力下降,并降低了正弦波光栅调制传递函数(MTF),但双闪光分辨率却得到了提高。本文根据轴突脱髓鞘模式提出了一种解释。中频闪烁诱发电位测试似乎是一种比双闪光视野计或知觉延迟视野计更不可靠的监测多发性硬化症患者脱髓鞘进展的方法,尽管在某些情况下诱发电位测试的客观性会具有优势。