Fritz H, Husberg B
Clin Exp Immunol. 1969 Jun;4(6):685-90.
In rabbits immunized against allotype specificities local dermal reactions were produced by intradermal injections of the appropriate allotype antigen. The reactions were characterized by redness of the skin, infiltration and oedema. The reactions initially appeared about 24 hr after the intradermal injections. In fully immunized rabbits they appeared about 4 hr after the injections. The reactions appearing after 4 hr were histologically characterized by perivascular polymorphonuclear leucocyte infiltration, extravasation of blood corpuscles and endothelial swelling. The dermal reactivity could be prevented by pretreatment of the animal with cyclophosphamide. Antihistamine treatment did not suppress the reactivity. The reaction appeared to be of Arthus type.
在针对同种异型特异性进行免疫的兔子中，通过皮内注射适当的同种异型抗原可产生局部皮肤反应。这些反应的特征是皮肤发红、浸润和水肿。反应最初在皮内注射后约24小时出现。在完全免疫的兔子中，它们在注射后约4小时出现。4小时后出现的反应在组织学上的特征是血管周围多形核白细胞浸润、血细胞外渗和内皮肿胀。用环磷酰胺对动物进行预处理可预防皮肤反应性。抗组胺治疗不能抑制反应性。该反应似乎属于阿瑟斯型。
