Liao W C, Zatz J L
J Pharm Sci. 1979 Apr;68(4):486-8. doi: 10.1002/jps.2600680425.
Contact angles of various liquids and surfactant solutions on polytef and paraffin were measured. Critical surface tension values were obtained by extrapolation of plots of cosine of the contact angles versus corresponding surface tension values. Contact angles measured using polyoxyethylene octylphenols produced linear Zisman plots and yielded critical surface tensions that agreed with accepted values. This liquid series provides a reasonable approach to the measurement of critical surface tension for solid drugs that are soluble in organic liquids but relatively insoluble in water.
测量了各种液体和表面活性剂溶液在聚四氟乙烯和石蜡上的接触角。通过将接触角的余弦值与相应表面张力值的关系图进行外推，获得了临界表面张力值。使用聚氧乙烯辛基酚测量的接触角产生了线性的齐斯曼图，并得出了与公认值一致的临界表面张力。该液体系列为测量可溶于有机液体但相对不溶于水的固体药物的临界表面张力提供了一种合理的方法。
