输精管切除术对豚鼠睾丸代谢的影响。
The effects of vasectomy on testicular metabolism in the guinea-pig.
作者信息
Howards S S, Flickinger C J, Noller D W, Panko W B
出版信息
J Reprod Fertil. 1979 Mar;55(2):401-5. doi: 10.1530/jrf.0.0550401.
The effects of vasectomy on testicular DNA production were studied in guinea-pigs at 2 weeks and 2 and 6 months after surgery. By 6 months, vasectomy had resulted in lower testicular weight and absolute DNA, RNA and protein contents, although RNA and DNA concentrations/protein were unchanged. Incorporation of thymidine into the testis had decreased by 2 weeks after vasectomy, and continued to do so unless the ductal system subsequently ruptured and formed a granuloma when thymidine incorporation returned to normal control levels. It is suggested that in the guinea=pig vasectomy alters spermatogenesis by reducing testicular DNA synthesis.
在豚鼠身上，研究了输精管结扎术后2周、2个月和6个月对睾丸DNA生成的影响。到6个月时，输精管结扎导致睾丸重量降低，DNA、RNA和蛋白质的绝对含量减少，尽管RNA和DNA浓度/蛋白质含量没有变化。输精管结扎术后2周，睾丸中胸苷的掺入量就已减少，并且除非随后导管系统破裂并形成肉芽肿，此时胸苷掺入量恢复到正常对照水平，否则会持续减少。有人认为，在豚鼠中，输精管结扎通过减少睾丸DNA合成来改变精子发生。
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