去氧肾上腺素对豚鼠盲肠带的抑制性α-肾上腺素能作用。

Inhibitory alpha-adrenergic action of phenylephrine in guinea pig taenia caecum.

作者信息

Iwayama Y, Takayanagi I, Kasuya Y

出版信息

Jpn J Pharmacol. 1979 Jun;29(3):349-56. doi: 10.1254/jjp.29.349.

DOI:10.1254/jjp.29.349

Abstract

Phenylephrine, a selective alpha-adrenergic stimulant, caused a maximal relaxation of the taenia from guinea pig caecum in the concentration of 10(-6) g/ml. Phenylephrine in this concentration did not influence intracellular cyclic AMP and cyclic GMP levels. Although phenylephrine abolished the spontaneous spike discharge, no change was detected in 45Ca-uptake and 45Ca-efflux on the tissue level after phenylephrine. Ca-uptake and Ca-release on the subcellular level were also not influenced by phenylephrine. In Ca free-solution phenylephrine inhibited the response to CaCl2. Phenylephrine increased 42K-efflux in the normally polarized taenia and also in the K-depolarized taenia.

摘要

去氧肾上腺素是一种选择性α-肾上腺素能兴奋剂，在浓度为10(-6) g/ml时可使豚鼠盲肠带达到最大舒张。该浓度的去氧肾上腺素不影响细胞内环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）水平。尽管去氧肾上腺素消除了自发性峰电位发放，但在组织水平上，去氧肾上腺素处理后45Ca摄取和45Ca外流未检测到变化。亚细胞水平的Ca摄取和Ca释放也不受去氧肾上腺素影响。在无钙溶液中，去氧肾上腺素抑制对氯化钙的反应。去氧肾上腺素增加了正常极化的盲肠带以及钾去极化的盲肠带中的42K外流。