Manicourt D H, Orloff S
J Rheumatol. 1979 Jan-Feb;6(1):57-64.
A young female with osteomalacia complicating a blind loop syndrome associated with congenital megaduodenum is described. In this case, the correction of vitamin D malabsorption by administration of antibiotics highlights the role of massive intraluminal bacterial overgrowth from destruction of vitamin D, or decreased unicellar solubilization due to deconjugation of biliary acids. The importance of cutaneous vitamin D synthesis in patients with osteomalacia of gastrointestinal origin is emphasized. The detection of megaduodenum and megaesophagus in the patient's father may be the first report of a familial association of these gastrointestinal abnormalities.
本文描述了一名患有骨软化症的年轻女性，该骨软化症并发与先天性巨十二指肠相关的盲袢综合征。在这种情况下，通过使用抗生素纠正维生素D吸收不良，凸显了维生素D被破坏导致大量肠腔内细菌过度生长，或因胆汁酸去结合导致单细胞溶解减少的作用。强调了皮肤维生素D合成在胃肠道源性骨软化症患者中的重要性。在患者父亲中检测到巨十二指肠和巨食管，这可能是这些胃肠道异常家族关联的首次报道。
