Gordon G V, Schumacher H R
J Rheumatol. 1979 Jan-Feb;6(1):7-14.
Depot corticosteroid crystals and their in vivo handling after intra-articular injection have not been studied by electron microscope (EM). We therefore injected 20 mg of either prednisolone tebuate or triamcinolone hexacetonide into knee joints of 7 patients with osteoarthritis and painful effusions. Six patients had a rise in the synovial fluid leukocyte counts, but only 1 patient had clinical evidence of a post-injection flare. Scanning and transmission EM revealed intra- and extracellular crystals 24 hours and 1 week after the initial injection. These combined EM studies provide an adjunct to compensated polarized microscopy in differentiation of depot steroid from other crystals.
关节内注射后长效皮质类固醇晶体及其体内处理情况尚未通过电子显微镜（EM）进行研究。因此，我们将20mg的醋酸特布他林泼尼松龙或己曲安奈德注射到7例患有骨关节炎且伴有疼痛性积液的患者膝关节中。6例患者的滑液白细胞计数升高，但只有1例患者有注射后炎症发作的临床证据。扫描电子显微镜和透射电子显微镜显示，在初次注射后24小时和1周时，细胞内和细胞外均有晶体。这些联合电子显微镜研究为补偿偏振显微镜鉴别长效类固醇与其他晶体提供了辅助手段。
