Levitan I B, Webb T E
Science. 1970 Jan 16;167(3916):283-5. doi: 10.1126/science.167.3916.283.
The purine analog azaguanine does not inhibit the initial induction of hepatic tyrosine transaminase by hydrocortisone. However, the continued induced synthesis of tyrosine transaminase, elicited by repeated doses of hydro-cortisone, is inhibited approximately 64 percent in the presence of the analog after 7 to 8 hours and appears to be almost completely inhibited by 9 to 10 hours; this suggests that the induction cycle involves the activation and renewal of a pool of preexisting messenger RNA.
嘌呤类似物氮杂鸟嘌呤并不抑制氢化可的松对肝酪氨酸转氨酶的初始诱导作用。然而，在重复给予氢化可的松所引发的酪氨酸转氨酶的持续诱导合成过程中，在存在该类似物的情况下，7至8小时后约64%受到抑制，到9至10小时似乎几乎完全被抑制；这表明诱导循环涉及到一组预先存在的信使核糖核酸的激活和更新。
