心绞痛的预防性治疗。阿普洛尔与戊四硝酯的双盲交叉对照比较。
Prophylactic treatment of angina pectoris. A double-blind cross-over comparison of alprenolol and pentanitrol.
作者信息
Aubert A, Nyberg G, Slaastad R, Tjeldflaat L
出版信息
Br Med J. 1970 Jan 24;1(5690):203-6. doi: 10.1136/bmj.1.5690.203.
Abstract
Twenty-one patients with angina pectoris took part in a double-blind cross-over comparison of alprenolol (an adrenergic beta-blocker), pentanitrol (pentaerythritol tetranitrate), and placebo. Two-thirds of the patients were clinically improved on alprenolol 100 mg. four times daily, which was found to be significantly better than pentanitrol 30 mg. four times daily and placebo. There was also an indication of reduced severity of anginal attacks during alprenolol therapy. It is concluded that success in at least two-thirds can be expected with alprenolol. No serious complications or side-effects occurred during alprenolol treatment.
摘要
21例心绞痛患者参与了阿普洛尔（一种肾上腺素能β受体阻滞剂）、戊四硝酯（季戊四醇四硝酸酯）和安慰剂的双盲交叉对照试验。三分之二的患者服用阿普洛尔100毫克，每日4次，临床症状得到改善，结果发现这明显优于每日4次服用30毫克戊四硝酯和安慰剂。在阿普洛尔治疗期间，还有迹象表明心绞痛发作的严重程度有所减轻。得出的结论是，使用阿普洛尔有望使至少三分之二的患者获得成功。在阿普洛尔治疗期间未发生严重并发症或副作用。
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Prophylactic treatment of angina pectoris. A double-blind cross-over comparison of alprenolol and pentanitrol.心绞痛的预防性治疗。阿普洛尔与戊四硝酯的双盲交叉对照比较。
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本文引用的文献
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Beta-adrenergic receptor blocking drugs. Mechanisms of action and clinical applications.β-肾上腺素能受体阻断药物。作用机制与临床应用。
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