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1
Prophylactic treatment of angina pectoris. A double-blind cross-over comparison of alprenolol and pentanitrol.心绞痛的预防性治疗。阿普洛尔与戊四硝酯的双盲交叉对照比较。
Br Med J. 1970 Jan 24;1(5690):203-6. doi: 10.1136/bmj.1.5690.203.
2
Alprenolol alone and in conjunction with pentanitrol in angina pectoris. A double-blind study with exercise tests.
Acta Med Scand. 1973 May;193(5):419-24. doi: 10.1111/j.0954-6820.1973.tb10603.x.
3
Alprenolol in angina pectoris. A clinical and ergometric study with a new beta-adrenergic blocking agent.心得舒治疗心绞痛。一项关于新型β-肾上腺素能阻滞剂的临床与测力计研究。
Ann Clin Res. 1969 May;1(1):13-21.
4
Trasicor in angina pectoris: a double-blind trial.心得安治疗心绞痛：一项双盲试验。
Br Med J. 1969 Apr 19;2(5650):155-7. doi: 10.1136/bmj.2.5650.155.
5
Exercise tolerance in patients with angina pectoris. Daily variation and effects of erythrityl tetranitrate, propranolol and alprenolol.心绞痛患者的运动耐量。四硝酸赤藓醇、普萘洛尔和阿普洛尔的每日变化及影响
Am J Cardiol. 1971 Jul;28(1):10-6. doi: 10.1016/0002-9149(71)90028-2.
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[Beta-blocking agents in angina pectoris. A double-blind trial].[β受体阻滞剂治疗心绞痛。一项双盲试验]
Tidsskr Nor Laegeforen. 1970 Feb 15;90(4):409-13 passim.
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Comparison of adrenergic beta-blocking drugs in angina pectoris.肾上腺素能β受体阻滞剂在心绞痛治疗中的比较。
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Acute effects of oral alprenolol on exercise tolerance in patients with angina pectoris. A dose-response study.口服阿普洛尔对心绞痛患者运动耐量的急性影响。一项剂量反应研究。
Br Heart J. 1971 Jul;33(4):481-8. doi: 10.1136/hrt.33.4.481.
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Lidoflazine: double-blind trial of a new coronary vasodilator in angina pectoris.利多氟嗪：一种新型冠状动脉血管扩张剂治疗心绞痛的双盲试验。
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4
Beta-adrenergic receptor blocking drugs in angina pectoris.β-肾上腺素能受体阻滞剂在心绞痛中的应用。
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Clinical experience with Imdur in angina pectoris. A review.
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本文引用的文献

1
Synthesis of some beta-adrenergic blocking agents.某些β-肾上腺素能阻滞剂的合成
Acta Pharm Suec. 1966 Sep;3(4):303-10.
2
Beta-adrenergic receptor blocking drugs. Mechanisms of action and clinical applications.β-肾上腺素能受体阻断药物。作用机制与临床应用。
N Engl J Med. 1966 Nov 17;275(20):1106-12 contd. doi: 10.1056/NEJM196611172752006.
3
Developmental mechanism of angina pectoris and action of coronary vasodilators.心绞痛的发病机制及冠状血管扩张剂的作用
Jpn Heart J. 1967 May;8(3):219-33. doi: 10.1536/ihj.8.219.
4
Regulation of coronary blood flow.冠状动脉血流的调节
Bull N Y Acad Med. 1966 Nov;42(11):940-50.
5
Treatment of angina pectoris with beta-receptor blockade, mode of action.
Acta Med Scand. 1968 Oct;184(4):259-62. doi: 10.1111/j.0954-6820.1968.tb02453.x.
6
Propranolol in the therapy of angina pectoris.普萘洛尔在心绞痛治疗中的应用。
Am J Cardiol. 1966 Sep;18(3):366-9. doi: 10.1016/0002-9149(66)90055-5.
7
The treatment of angina pectoris with a new beta-receptor blocking agent (H 56/28).用一种新型β受体阻滞剂（H 56/28）治疗心绞痛。
Acta Med Scand. 1967 Sep;182(3):285-91. doi: 10.1111/j.0954-6820.1967.tb11525.x.
8
Alprenolol in angina pectoris. A clinical and ergometric study with a new beta-adrenergic blocking agent.心得舒治疗心绞痛。一项关于新型β-肾上腺素能阻滞剂的临床与测力计研究。
Ann Clin Res. 1969 May;1(1):13-21.

心绞痛的预防性治疗。阿普洛尔与戊四硝酯的双盲交叉对照比较。

Prophylactic treatment of angina pectoris. A double-blind cross-over comparison of alprenolol and pentanitrol.

作者信息

Aubert A, Nyberg G, Slaastad R, Tjeldflaat L

出版信息

Br Med J. 1970 Jan 24;1(5690):203-6. doi: 10.1136/bmj.1.5690.203.

DOI:10.1136/bmj.1.5690.203
PMID:4391702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1699297/
Abstract

Twenty-one patients with angina pectoris took part in a double-blind cross-over comparison of alprenolol (an adrenergic beta-blocker), pentanitrol (pentaerythritol tetranitrate), and placebo. Two-thirds of the patients were clinically improved on alprenolol 100 mg. four times daily, which was found to be significantly better than pentanitrol 30 mg. four times daily and placebo. There was also an indication of reduced severity of anginal attacks during alprenolol therapy. It is concluded that success in at least two-thirds can be expected with alprenolol. No serious complications or side-effects occurred during alprenolol treatment.

摘要

21例心绞痛患者参与了阿普洛尔（一种肾上腺素能β受体阻滞剂）、戊四硝酯（季戊四醇四硝酸酯）和安慰剂的双盲交叉对照试验。三分之二的患者服用阿普洛尔100毫克，每日4次，临床症状得到改善，结果发现这明显优于每日4次服用30毫克戊四硝酯和安慰剂。在阿普洛尔治疗期间，还有迹象表明心绞痛发作的严重程度有所减轻。得出的结论是，使用阿普洛尔有望使至少三分之二的患者获得成功。在阿普洛尔治疗期间未发生严重并发症或副作用。