心得安治疗心绞痛：一项双盲试验。
Trasicor in angina pectoris: a double-blind trial.
作者信息
Wilson D F, Watson O F, Peel J S, Turner A S
出版信息
Br Med J. 1969 Apr 19;2(5650):155-7. doi: 10.1136/bmj.2.5650.155.
Abstract
Eighteen patients entered a double-blind trial of the beta-adrenergic blocking drug Trasicor in the treatment of angina pectoris. Six patients had to be withdrawn from the trial when substitution of placebo for Trasicor caused severe exacerbation of angina attacks. In these cases the frequency and severity of angina attacks fell to a minimum when Trasicor was re-established. A further 10 patients were significantly improved by Trasicor. Two patients showed no significant improvement. No side-effects were observed in doses ranging up to 400 mg. daily.
摘要
18名患者参与了β-肾上腺素能阻滞剂心得宁治疗心绞痛的双盲试验。当用安慰剂替代心得宁时，6名患者心绞痛发作严重加剧，不得不退出试验。在这些病例中，重新使用心得宁后，心绞痛发作的频率和严重程度降至最低。另有10名患者使用心得宁后有显著改善。2名患者无明显改善。每日剂量高达400毫克时未观察到副作用。
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N Z Med J. 1968 Mar;67(430):406-7.
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