角叉菜胶在大鼠体内的一些药效学特性。
Some pharmacodynamic properties of carrageenin in the rat.
作者信息
Di Rosa M, Sorrentino L
出版信息
Br J Pharmacol. 1970 Jan;38(1):214-20. doi: 10.1111/j.1476-5381.1970.tb10350.x.
Abstract
- Carrageenin oedema is suppressed by pre-treating the rats with cellulose sulphate, a kininogen depleting agent. This inhibition is closely related to the dose of cellulose sulphate and to the time course of kininogen depletion.2. Oedema induced by egg white or by dextran, in which the mediators are histamine and 5-hydroxytryptamine, is quite unaffected by cellulose sulphate treatment.3. Carrageenin injected intravenously lowers the arterial blood pressure of rats. This hypotensive effect is unaffected by histamine antagonists and is abolished by protease inhibitors and thus seems to be due to kinin release from plasma substrates.4. Like cellulose sulphate, carrageenin enhances the esterolytic activity of the blood from treated rats when incubated with benzoyl-arginine ethyl ester.5. The ability of carrageenin to activate the kinin-forming system could account for both its inflammatory and hypotensive effects.
摘要
用激肽原耗竭剂硫酸纤维素预处理大鼠，可抑制角叉菜胶性水肿。这种抑制作用与硫酸纤维素的剂量以及激肽原耗竭的时间进程密切相关。
由蛋清或右旋糖酐诱导的水肿，其介质为组胺和5-羟色胺，硫酸纤维素处理对其完全没有影响。
静脉注射角叉菜胶可降低大鼠的动脉血压。这种降压作用不受组胺拮抗剂的影响，但被蛋白酶抑制剂消除，因此似乎是由于血浆底物释放激肽所致。
与硫酸纤维素一样，角叉菜胶与苯甲酰精氨酸乙酯一起孵育时，可增强处理过的大鼠血液的酯解活性。
角叉菜胶激活激肽形成系统的能力可以解释其炎症和降压作用。
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