Finch W R, Strottman M P
JAMA. 1979 Jun 15;241(24):2616-8.
Three young women with systemic lupus erythematosus who were given ibuprofen for arthritis voluntarily discontinued taking the drug. On reinstitution of therapy, profound hypotension, fever, and headaches developed within hours, without other identifiable cause. A possible relationship to salicylate intolerance was considered. Because of these apparent side effects, we stress caution in the use of ibuprofen in systemic lupus erythematosus, particularly if there is any history of salicylate intolerance.
三名患有系统性红斑狼疮的年轻女性因关节炎服用布洛芬后，自行停药。再次用药后，数小时内出现严重低血压、发热和头痛，且无其他可识别的病因。考虑到可能与水杨酸盐不耐受有关。鉴于这些明显的副作用，我们强调在系统性红斑狼疮患者中使用布洛芬时要谨慎，尤其是有任何水杨酸盐不耐受病史的患者。
