Koeda T, Moriguchi M
Jpn J Antibiot. 1979 Feb;32(2):164-70.
The fertility study of fosfomycin-Na (FOM-Na) was undertaken in Wistar rats. FOM-Na was administered intraperitoneally at dose levels of 125, 250, 750 and 1,500 mg/kg/day. The male rats were continuously treated with FOM-Na from 63 days before mating and the females were treated from 14 days before mating. The males and females were treated through the mating period and then the pregnant rats were treated until 7 days of gestation. All pregnant rats were sacrificed on day 20 of gestation and then their fetuses were examined for external, visceral and skeletal observation. Mean body weight of males decreased and 6 males and 3 females died in the maximum dose. However, no significant differences were found between treated groups and the control with regard to fertility rate and pregnant rate. External, visceral and skeletal anomalies related with FOM-Na treatment were not observed. In this experiment, no effects of FOM-Na for reproductive performance in rats were observed.
对磷霉素钠（FOM-Na）进行了在Wistar大鼠中的生育力研究。FOM-Na以125、250、750和1500mg/kg/天的剂量水平腹腔注射给药。雄性大鼠在交配前63天开始连续用FOM-Na治疗，雌性大鼠在交配前14天开始治疗。雄性和雌性大鼠在交配期间接受治疗，然后怀孕大鼠接受治疗直至妊娠7天。所有怀孕大鼠在妊娠第20天处死，然后检查其胎儿的外观、内脏和骨骼情况。最大剂量组中雄性大鼠的平均体重下降，有6只雄性和3只雌性死亡。然而，在生育率和怀孕率方面，治疗组与对照组之间未发现显著差异。未观察到与FOM-Na治疗相关的外观、内脏和骨骼异常。在本实验中，未观察到FOM-Na对大鼠生殖性能的影响。
