磷霉素钠对大鼠生殖性能的影响。III. 围产期及产后检查（作者译）
[Effect of fosfomycin-Na on reproductive performance of rats. III. Peri- and post-natal examination (author's transl)].
作者信息
Koeda T, Moriguchi M
出版信息
Jpn J Antibiot. 1979 Feb;32(2):171-9.
PMID:439388
Abstract
The peri- and post-natal study of fosfomycin-Na (FOM-Na) was undertaken in Wistar rats. FOM-Na was administered intraperitoneally at dose levels of 250, 750 and 1,500 mg/kg/day from day 14 of gestation to day 21 after delivery. It could be concluded that delivery rate in the 750 and 1,500 mg/kg groups decreased, but no influence of FOM-Na was found on postnatal development of offspring (F1) and neonate (F2) without maximum dose.
摘要
对磷霉素钠（FOM-Na）进行了Wistar大鼠的围产期和产后研究。从妊娠第14天至产后第21天，以250、750和1500mg/kg/天的剂量水平腹腔注射FOM-Na。可以得出结论，750和1500mg/kg组的分娩率下降，但未发现FOM-Na对无最大剂量的后代（F1）和新生儿（F2）的产后发育有影响。
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