胸腺与骨髓在产生移植物抗宿主脾肿大中的协同作用 希尔加德HR：胸腺与骨髓在X线照射宿主产生移植物抗宿主脾肿大中的协同作用
Synergism of thymus and bone marrow in the production of gra a5hilgard HR: Synergism of thymus and bone marrow in the production of graft-versus-host splenomegaly in x-irradiated hosts.
作者信息
Hilgard H R
出版信息
J Exp Med. 1970 Aug 1;132(2):317-28. doi: 10.1084/jem.132.2.317.
Abstract
Graft-versus-host splenomegaly may be elicited from 500 R X-irradiated F(1) hybrid hosts if the hosts are injected with bone marrow cells and thymus cells from parental strain donors. Cells from thymus only or bone marrow only will not elicit graft-versus-host splenomegaly in these hosts. In this requirement for cells from both sources, the bone marrow cells play a nonimmunologic, proliferative role in the splenomegaly, and the thymus cells carry out the immunologic attack. Thus the mechanism of this synergism is quite different from that reported for the humoral immune response to sheep erythrocytes in which both thymus and marrow interact in the production of the specific immunologic response itself.
摘要
如果给500只经X射线照射的F(1)杂种宿主注射来自亲本品系供体的骨髓细胞和胸腺细胞，就可能引发移植物抗宿主脾肿大。仅来自胸腺的细胞或仅来自骨髓的细胞不会在这些宿主中引发移植物抗宿主脾肿大。在对来自这两种来源细胞的这种需求中，骨髓细胞在脾肿大中起非免疫性的增殖作用，而胸腺细胞则进行免疫攻击。因此，这种协同作用的机制与报道的对绵羊红细胞的体液免疫反应的机制截然不同，在后者中，胸腺和骨髓在特异性免疫反应本身的产生过程中相互作用。
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Synergism of thymus and bone marrow in the production of gra a5hilgard HR: Synergism of thymus and bone marrow in the production of graft-versus-host splenomegaly in x-irradiated hosts.胸腺与骨髓在产生移植物抗宿主脾肿大中的协同作用 希尔加德HR：胸腺与骨髓在X线照射宿主产生移植物抗宿主脾肿大中的协同作用
J Exp Med. 1970 Aug 1;132(2):317-28. doi: 10.1084/jem.132.2.317.
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J Exp Med. 1971 Sep 1;134(3 Pt 1):801-14. doi: 10.1084/jem.134.3.801.
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Thymocytes from mice immunized against an allograft render bone-marrow cells specifically cytotoxic.用同种异体移植物免疫的小鼠的胸腺细胞可使骨髓细胞具有特异性细胞毒性。
J Exp Med. 1972 Jan;135(1):150-64. doi: 10.1084/jem.135.1.150.
3
A cellular deficit in the reconstitutive capacity of immune populations of lymphoid cells demonstrable in studies of delayed hypersensitivity in mice. Evidence for thymus-bone marrow cell synergism.在小鼠迟发型超敏反应研究中可证实的淋巴细胞免疫群体重建能力的细胞缺陷。胸腺 - 骨髓细胞协同作用的证据。
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