介导移植物抗宿主反应的淋巴细胞间的协同作用。3. 两类胸腺来源细胞间相互作用的证据。
Synergy among lymphoid cells mediating the graft-versus-host response. 3. Evidence for interaction between two types of thymus-derived cells.
作者信息
Cantor H, Asofsky R
出版信息
J Exp Med. 1972 Apr 1;135(4):764-79. doi: 10.1084/jem.135.4.764.
Abstract
Two types of thymus-derived (T) lymphocytes have been shown to cooperate in the induction of graft-versus-host responses. One cell type is found in highest concentrations in the peripheral blood and lymph node, is extremely sensitive to anti-thymocyte serum (ATS) in vivo, and is probably part of the recirculating lymphoid cell pool (3). The second cell type, found in highest concentrations in the thymus and spleen, is relatively resistant to small doses of ATS in vivo. Both cell types are substantially depleted after neonatal thymectomy. Moreover, since synergism was also obtained using appropriate mixtures of cells from either parental strain in F(1) hosts, it was possible to show that the nonrecirculating cells determined the specificity of the response and were probably the precursors of effector cells in this response. The recirculating T cell appeared to amplify this response. The implications of these data are discussed.
摘要
已证明两种胸腺来源的（T）淋巴细胞在移植物抗宿主反应的诱导中协同作用。一种细胞类型在外周血和淋巴结中浓度最高，在体内对抗胸腺细胞血清（ATS）极为敏感，可能是循环淋巴样细胞池的一部分（3）。第二种细胞类型在胸腺和脾脏中浓度最高，在体内对小剂量ATS相对抗性。两种细胞类型在新生期胸腺切除后均大量减少。此外，由于在F（1）宿主中使用来自任一亲本菌株的细胞的适当混合物也获得了协同作用，因此有可能表明非循环细胞决定了反应的特异性，并且可能是该反应中效应细胞的前体。循环T细胞似乎放大了这种反应。讨论了这些数据的意义。
相似文献
1
Synergy among lymphoid cells mediating the graft-versus-host response. 3. Evidence for interaction between two types of thymus-derived cells.介导移植物抗宿主反应的淋巴细胞间的协同作用。3. 两类胸腺来源细胞间相互作用的证据。
J Exp Med. 1972 Apr 1;135(4):764-79. doi: 10.1084/jem.135.4.764.
2
The role of the thymus in development of immunologic capacity in rabbits and mice.胸腺在兔和小鼠免疫能力发育中的作用。
J Exp Med. 1962 Nov 1;116(5):773-96. doi: 10.1084/jem.116.5.773.
3
Synergy among lymphoid cells mediating the graft-versus-host response. II. Synergy in graft-versus-host reactions produced by Balb-c lymphoid cells of differing anatomic origin.介导移植物抗宿主反应的淋巴细胞间的协同作用。II. 不同解剖学来源的Balb-c淋巴细胞产生的移植物抗宿主反应中的协同作用。
J Exp Med. 1970 Feb;131(2):235-46. doi: 10.1084/jem.131.2.235.
4
Interaction of thymus lymphocytes with histoincompatible cells. 3. Immunological characteristics of recirculating lymphocytes derived from activated thymus cells.胸腺淋巴细胞与组织不相容细胞的相互作用。3. 源自活化胸腺细胞的再循环淋巴细胞的免疫学特性。
Cell Immunol. 1972 Feb;3(2):213-30. doi: 10.1016/0008-8749(72)90161-x.
5
Synergy among lymphoid cells mediating the graft-versus-host response. V. Derivation by migration in lethally irradiated recipients of two interacting subpopulations of thymus-derived cells from normal spleen.介导移植物抗宿主反应的淋巴细胞间的协同作用。V. 来自正常脾脏的胸腺衍生细胞的两个相互作用亚群在受致死性照射的受体中通过迁移的衍生过程。
J Exp Med. 1973 Feb 1;137(2):239-53. doi: 10.1084/jem.137.2.239.
6
Thymosin, a thymic hormone influencing lymphoid cell immunological competence.胸腺素，一种影响淋巴细胞免疫能力的胸腺激素。
Ciba Found Study Group. 1970;36:3-23.
7
Lymphocyte environment and the durability of transplantation tolerance.淋巴细胞环境与移植耐受的持久性
Transplant Proc. 1972 Sep;4(3):395-9.
8
Conferment of immunocompetence on lymphoid cells by a thymic humoral factor.胸腺体液因子赋予淋巴细胞免疫活性。
Ciba Found Study Group. 1970;36:24-41.
9
10
Protection of lethally irradiated mice by spleen cells from neonatally thymectomized mice.新生期胸腺切除小鼠的脾细胞对致死性照射小鼠的保护作用。
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2544-8. doi: 10.1073/pnas.71.6.2544.
引用本文的文献
1
DCs at the center of help: Origins and evolution of the three-cell-type hypothesis.树突状细胞处于核心地位：三细胞假说的起源和演变。
J Exp Med. 2022 Jul 4;219(7). doi: 10.1084/jem.20211519. Epub 2022 May 11.
2
The Role of Regulatory T Cells in Epicutaneous Immunotherapy for Food Allergy.调节性 T 细胞在经皮免疫治疗食物过敏中的作用。
Front Immunol. 2021 Jul 8;12:660974. doi: 10.3389/fimmu.2021.660974. eCollection 2021.
3
Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm.特殊调节性T细胞综述：换个名字的玫瑰：从抑制性T细胞到调节性T细胞，从认可到过度热情。
Immunology. 2008 Jan;123(1):20-7. doi: 10.1111/j.1365-2567.2007.02779.x.
4
Special regulatory T-cell review: Regulation of immune responses--examining the role of T cells.特殊调节性T细胞综述：免疫反应的调节——审视T细胞的作用。
Immunology. 2008 Jan;123(1):13-6. doi: 10.1111/j.1365-2567.2007.02775.x.
5
6
Helper activity of T lymphocytes which have been stimulated by keyhole limpet haemocyanin in vitro.体外被钥孔戚血蓝蛋白刺激的T淋巴细胞的辅助活性。
Immunology. 1981 May;43(1):111-6.
7
Antigen- and receptor-driven regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenearsonate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive-idiotype-positive, p-azobenzenearsonate-primed T cell target.抗原和受体驱动的调节机制。VIII. 抗独特型二级T抑制细胞与交叉反应性独特型阳性、对氨基苯砷酸致敏的T细胞靶标的相互作用导致对独特型阴性、对氨基苯砷酸特异性T细胞的抑制。
J Exp Med. 1981 Jun 1;153(6):1415-25. doi: 10.1084/jem.153.6.1415.
8
Allosuppressor and allohelper T cells in acute and chronic graft-vs.-host disease. II. F1 recipients carrying mutations at H-2K and/or I-A.急性和慢性移植物抗宿主病中的同种抑制性和同种辅助性T细胞。II. 在H-2K和/或I-A携带突变的F1受体。
J Exp Med. 1983 Feb 1;157(2):755-71. doi: 10.1084/jem.157.2.755.
9
Phenotypic and functional properties of murine thymocytes. I. Precursors of cytolytic T lymphocytes and interleukin 2-producing cells are all contained within a subpopulation of "mature" thymocytes as analyzed by monoclonal antibodies and flow microfluorometry.小鼠胸腺细胞的表型和功能特性。I. 用单克隆抗体和流式微量荧光测定法分析发现，溶细胞性T淋巴细胞和产生白细胞介素2的细胞的前体都包含在“成熟”胸腺细胞的一个亚群中。
J Exp Med. 1982 Feb 1;155(2):358-79. doi: 10.1084/jem.155.2.358.
10
B cell activation in vivo by nonantigen-specific interaction with T cells. Frequency of immune responses increased by immunization with two antigens.B细胞通过与T细胞的非抗原特异性相互作用在体内被激活。用两种抗原进行免疫接种可提高免疫反应的频率。
J Exp Med. 1972 Aug 1;136(2):381-6. doi: 10.1084/jem.136.2.381.
本文引用的文献
1
Studies on mouse leukaemia. The role of the thymus in leukaemogenesis by cell-free leukaemic filtrates.小鼠白血病研究。胸腺在无细胞白血病滤液致白血病过程中的作用。
Br J Cancer. 1960 Mar;14(1):93-8. doi: 10.1038/bjc.1960.11.
2
INVASION AND DESTRUCTION OF HOMOLOGOUS KIDNEY BY LOCALLY INOCULATED LYMPHOID CELLS.局部接种的淋巴细胞对同种肾的侵袭与破坏
J Exp Med. 1964 Sep 1;120(3):329-48. doi: 10.1084/jem.120.3.329.
3
Graft versus host reactions. Their natural history, and applicability as tools of research.移植物抗宿主反应。其自然史及其作为研究工具的适用性。
Prog Allergy. 1962;6:349-467.
4
Quantitative studies on the mixed lymphocyte interaction in rats. I. Conditions and parameters of response.大鼠混合淋巴细胞相互作用的定量研究。I. 反应的条件和参数。
J Exp Med. 1967 Oct 1;126(4):625-54. doi: 10.1084/jem.126.4.625.
5
Cell to cell interaction in the immune response. IV. Site of action of antilymphocyte globulin.免疫反应中的细胞间相互作用。IV. 抗淋巴细胞球蛋白的作用位点。
J Exp Med. 1968 Oct 1;128(4):855-74. doi: 10.1084/jem.128.4.855.
6
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
J Exp Med. 1968 Oct 1;128(4):821-37. doi: 10.1084/jem.128.4.821.
7
Effects of lymphoid depletion on the distribution of 51Cr-labeled lymph node cells in mice.淋巴细胞清除对51Cr标记的小鼠淋巴结细胞分布的影响。
Transplantation. 1971 Jun;11(6):536-42.
8
Nature and mode of action of antilymphocytic antiserum.抗淋巴细胞抗血清的性质与作用方式。
Proc Natl Acad Sci U S A. 1966 Oct;56(4):1130-7. doi: 10.1073/pnas.56.4.1130.
9
The carrier effect in the secondary response to hapten-protein conjugates. 3. The anatomical distribution of helper cells and antibody-forming-cell-precursors.对半抗原-蛋白质偶联物二次应答中的载体效应。3. 辅助性细胞和抗体形成细胞前体的解剖学分布。
Eur J Immunol. 1971 Apr;1(2):63-5. doi: 10.1002/eji.1830010202.
10
Studies on thymus function. I. Cooperative effect of thymic function and lymphohemopoietic cells in restoration of neonatally thymectomized mice.胸腺功能研究。I. 胸腺功能与淋巴造血细胞在新生期胸腺切除小鼠恢复中的协同作用。
J Exp Med. 1970 Sep 1;132(3):583-600. doi: 10.1084/jem.132.3.583.
Zotero 插件