白细胞氨基酸氧化酶与过氧化氢介导的细菌杀伤作用的关系。
Amino acid oxidase of leukocytes in relation to H 2 O 2 -mediated bacterial killing.
作者信息
Eckstein M R, Baehner R L, Nathan D G
出版信息
J Clin Invest. 1971 Sep;50(9):1985-91. doi: 10.1172/JCI106690.
Abstract
D-Amino acid oxidase and L-amino acid oxidase have been measured in sucrose homogenates of polymorphonuclear leukocytes (PMN) obtained from guinea pigs and humans. Subcellular distribution patterns and studies on latency indicate that these oxidases are soluble enzymes. Their hydrogen peroxide-generating capacity was verified. Chronic granulomatous disease PMN, which lack a respiratory burst and fail to generate H(2)O(2) during phagocytosis and do not kill catalase positive bacteria, had peroxide-generating amino acid oxidase activity equal to that found in PMN homogenates from patients with bacterial infections. The precise metabolic and bactericidal role of amino acid oxidases in PMN remains uncertain.
摘要
已对从豚鼠和人类获得的多形核白细胞（PMN）的蔗糖匀浆中的D-氨基酸氧化酶和L-氨基酸氧化酶进行了测定。亚细胞分布模式和潜伏性研究表明，这些氧化酶是可溶性酶。它们产生过氧化氢的能力得到了验证。慢性肉芽肿病的PMN缺乏呼吸爆发，在吞噬过程中无法产生H₂O₂，并且不能杀死过氧化氢酶阳性细菌，但其产生过氧化物的氨基酸氧化酶活性与细菌感染患者的PMN匀浆中的活性相当。氨基酸氧化酶在PMN中的确切代谢和杀菌作用仍不确定。
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