白细胞中的D-氨基酸氧化酶：一种可能的与D-氨基酸相关的抗菌系统。
D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system.
作者信息
Cline M J, Lehrer R I
出版信息
Proc Natl Acad Sci U S A. 1969 Mar;62(3):756-63. doi: 10.1073/pnas.62.3.756.
Abstract
D-Amino acid oxidase has been identified within the granule fraction of human neutrophilic leukocytes. Leukocyte homogenates and purified kidney D-amino acid oxidase can utilize either isolated D-amino acids or some species of bacteria as substrates for the generation of hydrogen peroxide. When linked to leukocyte myeloperoxidase in vitro, purified D-amino acid oxidase constitutes a system lethal for certain bacteria. It is proposed that leukocyte D-amino acid oxidase and myeloperoxidase constitute a biochemically specific system for the recognition and killing of certain microorganisms.
摘要
已在人类嗜中性白细胞的颗粒部分中鉴定出D-氨基酸氧化酶。白细胞匀浆和纯化的肾脏D-氨基酸氧化酶可以利用分离出的D-氨基酸或某些种类的细菌作为生成过氧化氢的底物。在体外与白细胞髓过氧化物酶连接时，纯化的D-氨基酸氧化酶构成了对某些细菌具有致死性的系统。有人提出，白细胞D-氨基酸氧化酶和髓过氧化物酶构成了一个用于识别和杀死某些微生物的生化特异性系统。
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Proc Natl Acad Sci U S A. 1969 Mar;62(3):756-63. doi: 10.1073/pnas.62.3.756.
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