巨噬细胞迁移抑制因子-1作为阿片拮抗剂的不同作用。

MIF-I's differential actions as an opiate antagonist.

作者信息

Kastin A J, Olson R D, Ehrensing R H, Berzas M C, Schally A V, Coy D H

出版信息

Pharmacol Biochem Behav. 1979 Dec;11(6):721-3. doi: 10.1016/0091-3057(79)90270-3.

Abstract

The effects of MIF-I (Pro-Leu-Gly-NH2) were examined in three experimental conditions in which the opiate antagonist naloxone is active. MIF-I was found to block the analgesic effects of enkephalins and also morphine in the tail-flick test but not in the vas deferens assay. Unlike naloxone, MIF-I did not seem to reduce food intake in VMH-lesioned rats. The results suggest the possibility that MIF-I may represent a class of naturally occurring opiate antagonists with varying activities in independent situations.

摘要

在阿片类拮抗剂纳洛酮发挥作用的三种实验条件下，研究了MIF-I（脯氨酸-亮氨酸-甘氨酸-氨基）的作用。在甩尾试验中，发现MIF-I可阻断脑啡肽和吗啡的镇痛作用，但在输精管试验中则不然。与纳洛酮不同，MIF-I似乎不会减少VMH损伤大鼠的食物摄入量。结果表明，MIF-I可能代表一类在不同情况下具有不同活性的天然存在的阿片类拮抗剂。