Reif-Lehrer L
J Cell Biol. 1971 Oct;51(1):303-11. doi: 10.1083/jcb.51.1.303.
Cortisol can prematurely induce glutamine synthetase activity in the chick embryo retina. Under appropriate conditions, this effect can be enhanced by addition of low levels of actinomycin D; this enhancement is reversibly inhibited by cycloheximide. The magnitude of the effect is a function of time of exposure to hormone as well as antibiotic and is also a function of the age of the embryo; within the limits of the present study it did not appear to be a function of actinomycin-D concentration. The data are discussed in terms of current ideas of possible control mechanisms in animal cells.
皮质醇可过早诱导鸡胚视网膜中的谷氨酰胺合成酶活性。在适当条件下,添加低水平的放线菌素D可增强这种效应;这种增强作用可被环己酰亚胺可逆性抑制。效应的大小是接触激素和抗生素时间的函数,也是胚胎年龄的函数;在本研究的范围内,它似乎不是放线菌素D浓度的函数。根据目前关于动物细胞可能的控制机制的观点对这些数据进行了讨论。