预防可卡因诱导的对儿茶酚胺超敏反应。

Protection against induction of supersensitivity to catecholamines by cocaine.

作者信息

Innes I R, Karr G W

出版信息

Br J Pharmacol. 1971 Aug;42(4):603-10. doi: 10.1111/j.1476-5381.1971.tb07144.x.

DOI:10.1111/j.1476-5381.1971.tb07144.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665740/

Abstract

Adrenaline, noradrenaline, isoprenaline, tyramine, phentolamine, pronethalol, histamine and acetylcholine were each tested for their ability to prevent cocaine from causing supersensitivity to catecholamines in cat spleen strips in vitro. A high concentration of one of these drugs was added to the bath 5 min before cocaine hydrochloride (10 mug/ml). The effect on subsequent responses to catecholamines was compared with the effect of cocaine in control strips in the absence of an interfering drug.2. Phentolamine completely abolished the potentiating effect of cocaine. Large doses of adrenaline or noradrenaline reduced, but did not completely prevent, potentiation. Tyramine, isoprenaline, pronethalol, histamine and acetylcholine did not prevent potentiation.3. The ability of these drugs to interfere with potentiation does not correlate well with their ability to interfere with uptake of noradrenaline. Interference with uptake by cocaine is therefore unlikely to account fully for potentiation.

摘要

分别测试了肾上腺素、去甲肾上腺素、异丙肾上腺素、酪胺、酚妥拉明、普萘洛尔、组胺和乙酰胆碱阻止可卡因在体外引起猫脾脏条对儿茶酚胺超敏反应的能力。在加入盐酸可卡因（10微克/毫升）前5分钟，将这些药物中的一种高浓度溶液加入浴槽。将其对随后儿茶酚胺反应的影响与无干扰药物时对照条中可卡因的作用进行比较。
酚妥拉明完全消除了可卡因的增强作用。大剂量的肾上腺素或去甲肾上腺素可减弱但不能完全阻止增强作用。酪胺、异丙肾上腺素、普萘洛尔、组胺和乙酰胆碱不能阻止增强作用。
这些药物干扰增强作用的能力与其干扰去甲肾上腺素摄取的能力相关性不佳。因此，可卡因对摄取的干扰不太可能完全解释增强作用。