可卡因对猫脾脏中异丙肾上腺素的增强作用与摄取抑制的解离。
Dissociation of potentiation of isoprenaline by cocaine from inhibition of uptake in cat spleen.
作者信息
Davidson W J, Innes I R
出版信息
Br J Pharmacol. 1970 May;39(1):175-81. doi: 10.1111/j.1476-5381.1970.tb09567.x.
Abstract
- Cocaine hydrochloride, 10 mug/ml, potentiated isoprenaline and noradrenaline in isolated spleen strips from normal cats and from cats treated with reserpine 24 h previously.2. Isoprenaline was taken up almost as well as noradrenaline by spleen strips from cats treated with reserpine.3. Cocaine blocked uptake of noradrenaline but did not reduce uptake of isoprenaline. Drug concentrations used in these studies were the same as in potentiation experiments.4. It is concluded that inhibition of uptake is not the mechanism by which cocaine potentiates the effect of isoprenaline on the spleen and might be only a contributory factor in the case of noradrenaline potentiation.
摘要
10微克/毫升的盐酸可卡因增强了正常猫以及提前24小时用利血平处理过的猫的离体脾条对异丙肾上腺素和去甲肾上腺素的反应。
用利血平处理过的猫的脾条对异丙肾上腺素的摄取情况与对去甲肾上腺素的摄取情况几乎相同。
可卡因阻断了去甲肾上腺素的摄取，但没有降低异丙肾上腺素的摄取。这些研究中使用的药物浓度与增强实验中的相同。
得出的结论是，摄取抑制不是可卡因增强异丙肾上腺素对脾脏作用的机制，在去甲肾上腺素增强作用的情况下，摄取抑制可能只是一个促成因素。
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