Humphrey L J, Volenec P J, Estes N C, Volenec F J
J Surg Oncol. 1979;11(2):141-52. doi: 10.1002/jso.2930110208.
Two antigens in specimens of human breast cancer have been identified as autoantigens. One antigen appears to be an IgG Fc fragment; the other, an IgG Fab fragment. Antibodies in sera of cancer patients directed against these antigens have also been identified. These autoantibodies occur in patients with breast cancer as well as other cancers, and rarely in patients with non-cancerous disease or in people screened in a detection center for breast diseases. The breast cancer patient found to have antibody directed against the IgG Fab antigen falls into a group that has improved two-year survival statistics over groups of patients who lack this antibody.
在人类乳腺癌标本中已鉴定出两种抗原为自身抗原。一种抗原似乎是IgG Fc片段；另一种是IgG Fab片段。也已鉴定出癌症患者血清中针对这些抗原的抗体。这些自身抗体存在于乳腺癌患者以及其他癌症患者中，而在非癌症疾病患者或乳腺癌疾病检测中心筛查的人群中很少出现。发现针对IgG Fab抗原产生抗体的乳腺癌患者，其两年生存率统计数据优于缺乏这种抗体的患者组。
