Libet B, Tosaka T
Proc Natl Acad Sci U S A. 1970 Oct;67(2):667-73. doi: 10.1073/pnas.67.2.667.
An analysis of the role of adrenergic transmission in mediating the hyperpolarizing, slow inhibitory postsynaptic potential has revealed that dopamine is apparently the specific synaptic transmitter for this response. An additional action of dopamine was discovered, namely the selective facilitation of another synaptic response, the slow excitatory postsynaptic potential. (This potential is a depolarizing response to the muscarinic action of acetylcholine.) This second, modulatory, role of dopamine has characteristics strikingly different from other known modes of synaptic action. After a brief initial action by dopamine, the facilitation of the slow excitatory postsynaptic potential response can persist for hours and is unaffected by a delayed blockade of the postsynaptic receptors for dopamine. This suggests that the modulation consists of a long-lasting metabolic and/or structural change induced in the postsynaptic neuron by dopamine. These conclusions are based on the demonstrated actions of dopamine and other catecholamines, as well as on effects (on dopamine actions and on slow postsynaptic potentials of alpha-adrenergic blockers, of blockade, of dopamine oxidase, of depletion of ganglionic catecholamine by muscarinic excitation, and of a selective re-uptake of dopamine after such depletion.
对肾上腺素能传递在介导超极化、缓慢抑制性突触后电位中的作用进行分析后发现，多巴胺显然是这种反应的特异性突触递质。还发现了多巴胺的另一种作用，即对另一种突触反应——缓慢兴奋性突触后电位的选择性易化作用。（这种电位是对乙酰胆碱毒蕈碱样作用的去极化反应。）多巴胺的这第二种调节作用具有与其他已知突触作用模式显著不同的特征。在多巴胺短暂的初始作用之后，对缓慢兴奋性突触后电位反应的易化作用可持续数小时，并且不受对多巴胺突触后受体的延迟阻断的影响。这表明这种调节作用包括多巴胺在突触后神经元中诱导的持久的代谢和/或结构变化。这些结论基于已证实的多巴胺和其他儿茶酚胺的作用，以及基于（对多巴胺作用和对α-肾上腺素能阻滞剂、多巴胺氧化酶阻断、毒蕈碱样兴奋导致神经节儿茶酚胺耗竭以及这种耗竭后多巴胺的选择性再摄取对缓慢突触后电位的）影响。
