[Concentrations of antibiotics (ampicilline, doxycycline) in the chronic-hyperplastic alterated mucosa of the maxillary sinuses (author's transl)].

Surgical treatment of chronic sinusitis is usually preceeded by the attempt of curing the disease by antibiotic and antiphlogistic therapy. Since no studies on the concentration of antibiotics in chronic-hyperplastic mucosa of the maxillary sinuses could be found in the literature, two groups of each 20 patients were subjected to treatment with ampicilline (Binotal) and doxycycline (Vibramycin) respectively and the concentrations of the antibiotics in the maxillary sinus tissue gained during operation were measured. It was shown that therapy with doxycycline produces higher tissue levels than with ampicilline. So it can be assumed that with doxycycline the treatment of chronic-hyperplastic sinusitis will be more frequently successful than with ampicilline. But, with regard to the tissue concentrations found in the study, also with doxycycline only part of infections (e. g. due to certain grampositive cocci, hemophilic bacteria, Pasteurellae) seems to be controllable. Since bacteria of different species could be isolated from the excided mucosa of about 50% of the patients and, on the other hand, the serum levels especially in case of doxycycline were constantly high, the prophylactic use of this drug before operation is recommended in order to avoid inflammatory complications.