Carenfelt C, Lundberg C
Scand J Infect Dis Suppl. 1976(9):78-81.
The elimination of bacteria from sinus secretion during antibiotic treatment and the biological environment in the sinus as regards pO2 and pCO2 of sinus secretions were studied. Elimination of bacteria was achieved only, but not invariably, when the antibiotic concentration in the secretion greatly exceeded the MIC values of the bacteria isolated. Bacteriostatic and bactericidal antibiotics were equally effective. In purulent secretions as opposed to nonpurulent secretions the pO2 was always zero or close to zero, and the pCO2 was always higher than, and sometimes more than twice as high as the pCO2 of venous blood. In view of these observations, antibiotic therapy resulting in a high antibiotic concentration in the secretion is advocated in the treatment of purulent maxillary sinusitis. Furthermore, drainage and aeration of the sinus cavity is to be regarded as an important complement to the antibiotic therapy.
研究了抗生素治疗期间鼻窦分泌物中细菌的清除情况以及鼻窦中关于鼻窦分泌物的氧分压（pO2）和二氧化碳分压（pCO2）的生物环境。只有当分泌物中的抗生素浓度大大超过分离出的细菌的最低抑菌浓度（MIC）值时，细菌才会被清除，但并非总是如此。抑菌性抗生素和杀菌性抗生素同样有效。与非脓性分泌物相反，脓性分泌物中的pO2始终为零或接近零，且pCO2始终高于静脉血的pCO2，有时高出两倍多。鉴于这些观察结果，提倡在治疗脓性上颌窦炎时采用能使分泌物中抗生素浓度较高的抗生素疗法。此外，鼻窦腔的引流和通气应被视为抗生素治疗的重要补充。
