Ekedahl C, Holm S E, Bergholm A M
Scand J Infect Dis Suppl. 1978(14):279-84.
A micro-method was developed for determination of the concentrations of antibiotics in the mucous membranes of the maxillary sinus in man. At different times after the administration of antibiotics (potassium phenoxymethylpenicillin, lymecycline and bacampicillin) the concentration was determined in serum and in pieces of maxillary sinus mucosa obtained at operation. It was found that the concentrations in the mucosa varied within wide ranges during the first 60 minutes after the operation but in samples taken at 90 minutes the fluctuations between the individuals were within the standard error of the method. Concentrations well above the MIC values for the majority of bacterias found in sinusitis were registered in the peaks. Six hours after the administration considerable amounts of active antibiotics were still detected in the maxillary sinus mucosa.
已开发出一种微量方法，用于测定人体上颌窦黏膜中抗生素的浓度。在给予抗生素（苯氧甲基青霉素钾、赖甲环素和巴氨西林）后的不同时间，测定血清以及手术时获取的上颌窦黏膜碎片中的浓度。结果发现，术后最初60分钟内，黏膜中的浓度变化范围很广，但在90分钟时采集的样本中，个体间的波动在该方法的标准误差范围内。峰值时记录到的浓度远高于在鼻窦炎中发现的大多数细菌的最低抑菌浓度值。给药6小时后，在上颌窦黏膜中仍检测到相当数量的活性抗生素。
