Büchel K H
Naturwissenschaften. 1979 Apr;66(4):173-81. doi: 10.1007/BF00366017.
Three concepts for the synthesis of biologically active compounds are discussed and illustrated by examples. In addition to the accidental finding of biologically active compounds, synthesized purely for chemical reasons, analogy models can serve as guidelines for synthesis. In the latter, naturally occurring or synthetic biologically active molecules are modified to optimize or alter the biological properties. A third approach for the synthesis of active substances is oriented according to the side of action. Models from biochemistry and molecular biology serve as a basis for synthesis planning.
本文讨论了三种合成生物活性化合物的概念，并举例进行了说明。除了纯粹出于化学原因合成而偶然发现的生物活性化合物外，类比模型可作为合成的指导。在后一种情况下，对天然存在的或合成的生物活性分子进行修饰，以优化或改变其生物学特性。合成活性物质的第三种方法是根据作用靶点进行设计。生物化学和分子生物学的模型为合成规划提供了基础。
