小鼠胸腺细胞的免疫特性。在一个较小的低密度亚群中鉴定T细胞功能。
Immunologic properties of mouse thymus cells. Identification of T cell functions within a minor, low-density subpopulation.
作者信息
Konda S, Nakao Y, Smith R T
出版信息
J Exp Med. 1972 Dec 1;136(6):1461-77. doi: 10.1084/jem.136.6.1461.
Abstract
The functional attributes of minor subpopulations of mouse thymus cells derived by bovine serum albumin density gradient centrifugation, cortisone treatment, or selective depletion by anti-TL or anti-theta treatment have been examined. A subpopulation derived in each fashion contains the cells required to evoke graft-versus-host reactions in neonatal F(1) hybrid recipients and to be stimulated by alloantigens in vitro in one-way mixed lymphocyte cultures and by phytohemagglutinin. The functions of this subpopulation are abrogated by treatment with anti-H-2 plus complement and by high concentrations of anti-theta. A tentative ordering of the various thymus cell subpopulations, on the basis of these and other data, is described.
摘要
通过牛血清白蛋白密度梯度离心、可的松处理或抗TL或抗θ处理进行选择性清除所获得的小鼠胸腺细胞亚群的功能特性已得到研究。以每种方式获得的一个亚群包含在新生F(1)杂种受体中引发移植物抗宿主反应以及在单向混合淋巴细胞培养中被同种异体抗原和植物血凝素体外刺激所需的细胞。用抗H-2加补体处理以及高浓度抗θ处理可消除该亚群的功能。基于这些及其他数据，描述了各种胸腺细胞亚群的初步排序。
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本文引用的文献
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