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被膜下胸腺淋巴母细胞暴露大豆凝集素受体。

Subcapsular thymic lymphoblasts expose receptors for soy bean lectin.

作者信息

Raedler A, Raedler E, Becker W M, Arndt R, Thiele H G

出版信息

Immunology. 1982 Jun;46(2):321-8.

PMID:7200955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555394/
Abstract

In the course of analysing thymic cellular constituents concerning the expression of lectin receptors and defined lymphocyte differentiation antigens, respectively, a subpopulation of thymic lymphocytes was detected exposing both peanut lectin (PNL) and soy bean lectin (SBL) receptors on their surfaces, while the majority of cortical thymic lymphocytes were found to be PNL positive, but SBL negative. This subset of SBL+PNL+thymic lymphocytes in the adult populates the area beneath the thymic capsule, forming a narrow rim only, while in perinatal thymus a corresponding subcapsular cell layer comprises almost one third of the thymic tissue and in early ontogenesis the vast majority of thymic lymphoid cells are PNL+SBL+. By ultrastructural analysis of double labelled cell suspensions as well as of cells separated by affinity chromatography, it could be shown that PNL/SBL+ cells frequently exhibit morphological features of lymphoblastic cells. Thus this subcapsularly located subset seems to represent a compartment of proliferating immature cells, descended from bone marrow and foetal liver prethymic cells, respectively, and giving rise to PNL/SBL- cortical thymic lymphocytes.

摘要

在分别分析胸腺细胞成分中凝集素受体的表达和特定淋巴细胞分化抗原的过程中，检测到胸腺淋巴细胞的一个亚群，其表面同时暴露花生凝集素（PNL）和大豆凝集素（SBL）受体，而大多数皮质胸腺淋巴细胞被发现为PNL阳性，但SBL阴性。在成年个体中，这个SBL+PNL+胸腺淋巴细胞亚群仅在胸腺被膜下方区域形成一个狭窄的边缘，而在围产期胸腺中，相应的被膜下细胞层几乎占胸腺组织的三分之一，并且在个体发育早期，绝大多数胸腺淋巴样细胞是PNL+SBL+。通过对双重标记细胞悬液以及通过亲和层析分离的细胞进行超微结构分析，可以表明PNL/SBL+细胞经常表现出成淋巴细胞的形态特征。因此，这个位于被膜下的亚群似乎代表了一个增殖的未成熟细胞区室，分别源自骨髓和胎肝胸腺前体细胞，并产生PNL/SBL-皮质胸腺淋巴细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/64f9f8741611/immunology00227-0088-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/ec28d84f7e21/immunology00227-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/97bf6fa37c6d/immunology00227-0085-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/b8622912a509/immunology00227-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/9aa7d5e0e927/immunology00227-0086-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/0de3d916483e/immunology00227-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/64f9f8741611/immunology00227-0088-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/ec28d84f7e21/immunology00227-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/97bf6fa37c6d/immunology00227-0085-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/b8622912a509/immunology00227-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/9aa7d5e0e927/immunology00227-0086-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/0de3d916483e/immunology00227-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df45/1555394/64f9f8741611/immunology00227-0088-b.jpg

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Subcapsular thymic lymphoblasts expose receptors for soy bean lectin.被膜下胸腺淋巴母细胞暴露大豆凝集素受体。
Immunology. 1982 Jun;46(2):321-8.
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引用本文的文献

1
The use of lectins to study normal differentiation and malignant transformation.利用凝集素研究正常分化与恶性转化。
J Cancer Res Clin Oncol. 1985;109(3):245-51. doi: 10.1007/BF00390364.

本文引用的文献

1
Plasma membrane cholesterol regulates human lymphocyte cytotoxic function.质膜胆固醇调节人类淋巴细胞的细胞毒性功能。
Eur J Immunol. 1980 Nov;10(11):821-7. doi: 10.1002/eji.1830101105.
2
Peanut lectin binding properties of germinal centres of mouse lymphoid tissue.小鼠淋巴组织生发中心的花生凝集素结合特性
Nature. 1980 Mar 27;284(5754):364-6. doi: 10.1038/284364a0.
3
Varying expressions of lectin receptors within embryonic cell layers of murine cerebral cortex.小鼠大脑皮质胚胎细胞层中凝集素受体的不同表达
Anat Embryol (Berl). 1981;162(1):21-8. doi: 10.1007/BF00318091.
4
Distribution of Lyt phenotypes in thymocyte subpopulations as measured by flow microfluorometry: selective enrichment of Lyt 1+23- thymocytes.通过流式微量荧光测定法检测的胸腺细胞亚群中Lyt表型的分布：Lyt 1+23-胸腺细胞的选择性富集。
J Immunol. 1980 May;124(5):2209-17.
5
Ultrastructure of the rat thymus: the micro-environment of T-lymphocyte maturation.大鼠胸腺的超微结构：T淋巴细胞成熟的微环境。
Cell Tissue Res. 1981;218(2):279-92. doi: 10.1007/BF00210344.
6
T cell ontogeny. Organ location of maturing populations as defined by surface antigen markers is similar in neonates and adults.T细胞个体发育。根据表面抗原标志物定义的成熟群体的器官定位在新生儿和成年人中相似。
J Exp Med. 1981 Mar 1;153(3):605-14. doi: 10.1084/jem.153.3.605.
7
Correspondence between lectin-defined and surface antigen-defined cell subpopulations in the human thymus: its variation during ontogeny.人胸腺中凝集素定义的细胞亚群与表面抗原定义的细胞亚群之间的对应关系：其在个体发育过程中的变化。
J Immunol. 1981 Jul;127(1):252-5.
8
Separation of antibody helper and antibody suppressor human T cells by using soybean agglutinin.利用大豆凝集素分离人抗体辅助性T细胞和抗体抑制性T细胞。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6778-82. doi: 10.1073/pnas.77.11.6778.
9
T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.由Lyt-1、2、3和Thy-1抗原表达所定义的T细胞亚群。使用单克隆抗体进行的双参数免疫荧光和细胞毒性分析改变了当前的观点。
J Exp Med. 1980 Aug 1;152(2):280-95. doi: 10.1084/jem.152.2.280.
10
A method for the quantitative modification and estimation of carboxylic acid groups in proteins.一种用于蛋白质中羧酸基团定量修饰和估算的方法。
J Biol Chem. 1967 May 25;242(10):2447-53.