Whitfield J B, Moss D W, Neale G, Orme M, Breckenridge A
Br Med J. 1973 Feb 10;1(5849):316-8. doi: 10.1136/bmj.1.5849.316.
A significant rise in plasma gamma-glutamyl transpeptidase activity (GGT) was observed on 13 out of 14 occasions on which patients on long-term treatment with the oral anticoagulant warfarin were given amylobarbitone, quinalbarbitone, or phenazone (antipyrine) for 30 days. In 13 of these 14 studies there was evidence that drug administration had stimulated the rate of warfarin metabolism. One patient showed no increase in plasma GGT activity, yet a significantly increased rate of warfarin metabolism, and another patient showed an increase in plasma GGT activity without a change in warfarin metabolism. When alterations in both plasma GGT activity and plasma warfarin concentration occurred together in response to drug administration the changes followed a similar time course, occurring after about one week of drug administration with maximal changes at about 10 or 15 days. Administration of chlordiazepoxide, diazepam, nitrazepam, and methaqualone did not stimulate the rate of warfarin metabolism in four patients studied, but plasma GGT activity increased significantly in two of these four instances. The implications of these observations in the interpretation of plasma GGT activities are discussed.
在14例接受口服抗凝剂华法林长期治疗的患者中，有13例在给予异戊巴比妥、喹巴比妥或非那宗（安替比林）30天的情况下，观察到血浆γ-谷氨酰转肽酶活性（GGT）显著升高。在这14项研究中的13项中，有证据表明给药刺激了华法林的代谢速率。1例患者血浆GGT活性未升高，但华法林代谢速率显著增加，另1例患者血浆GGT活性增加而华法林代谢无变化。当给药后血浆GGT活性和血浆华法林浓度同时发生改变时，变化遵循相似的时间进程，在给药约1周后出现，最大变化出现在约10或15天。在研究的4例患者中，给予氯氮卓、地西泮、硝西泮和甲喹酮并未刺激华法林的代谢速率，但在这4例中的2例血浆GGT活性显著增加。讨论了这些观察结果在解释血浆GGT活性方面的意义。
